May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Circadian Intraocular Pressure Fluctuations: Can We Really Estimate Them During Office Hours?
Author Affiliations & Notes
  • N. Orzalesi
    Eye Clinic, Department of Medicine, Surgery and Odontoiatry, San Paolo Hospital, Milan, Italy
  • P. Fogagnolo
    G.B. Bietti Foudation – IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Rome, Italy
  • A. Ferreras
    Miguel Servet University Hospital, Zaragoza, Spain
  • L. Rossetti
    Eye Clinic, Department of Medicine, Surgery and Odontoiatry, San Paolo Hospital, Milan, Italy
  • Footnotes
    Commercial Relationships  N. Orzalesi, None; P. Fogagnolo, None; A. Ferreras, None; L. Rossetti, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1054. doi:https://doi.org/
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      N. Orzalesi, P. Fogagnolo, A. Ferreras, L. Rossetti; Circadian Intraocular Pressure Fluctuations: Can We Really Estimate Them During Office Hours?. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1054. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To quantify the validity of estimating mean intraocular pressure (IOP) and its fluctuations when measured during office hours in comparison with 24-hr derived values.

Methods: : We retrospectively analysed 144 24-h IOP curves of 19 healthy adults (age: 69±4 years; F/M=10/9), 10 healthy youngs (age: 25±4 years; F/M=6/4) and 30 glaucomatous patients (age: 71±7 years; F/M=18/12). The glaucoma group included both untreated and medically treated patients (treatments: timolol, latanoprost, brimonidine, dorzolamide, fixed combination of dorzolamide and timolol). Measurements were taken at 8 pm, midnight, 4 am, 8 am, noon, and 4 pm, both at supine (Perkins handheld tonometer) and sitting (Goldmann tonometer) positions. IOP fluctuations were calculated as the mean of individual ranges.

Results: : During office hours (8 am, noon, 4 pm), mean IOP was slightly overestimated with respect to 24-hr (range, +(0.5-1.2) mmHg).The difference was statistically significant only for untreated glaucoma patients and for patients treated with the fixed combination of dorzolamide and timolol both in supine and sitting positions (P<0.01). IOP fluctuations during office hours were always significantly underestimated by about -(2-4) mmHg (P<0.05), regardless of body position.

Conclusions: : 24-hr IOP fluctuations are underestimated when assessed only during office hours.

Keywords: intraocular pressure 
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