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A. S. Reis, C. G. Vasconcelos-Moraes, R. M. Vessani, M. Hatanaka, M. E. Sano, R. Susanna, Jr.; Correlation Between Intraocular Pressure Rise, Ocular Pulse Amplitude and Choroidal Thickness During the Water Drinking Test. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1062.
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This report aims to study the correlation between intraocular pressure rise and choroid thickness (CT) during the WDT.
Primary Open Angle (POA) glaucomatous patients were recruited from the Glaucoma Center of the University of Sao Paulo School of Medicine during the period of 1 month. All patients were under topical treatment in both eyes during the study. The WDT was performed, using Goldman Applanation Tonometry (GAT) and Dynamic Contour Tonometer (DCT), right after each IOP measurement, ultrassonography examinations in both eyes using B scan were performed by the same ophthalmologist with subspecialty training in ocular USG.
Thirteen patients (26 eyes - not including controls) were studied. Their average age was 54.6 years; 66% were females and 80% Caucasians. In patients submitted to WDT, the mean IOP using GAT was 17.2 ±3.7 and 20.5 ±3.5 before and after the test, respectively (p<0.001). For the DCT, mean IOP was 16.2 ± 2.8 and 18.8 ±1.2 before and after the test, respectively (p<0.001). During the WDT, most IOP peaks occurred at 30 minutes from baseline measurement using both GAT and DCT. Mean OPA and mean CT also showed statistically significant increase during the WDT (p<0.001), while most of its peaks occurred approximately 15 minutes before the IOP peaks.
During the WDT, glaucomatous eyes showed an IOP increase using both GAT and DCT, as well as an increase in the OPA and CT. There is a moderate and significant correlation between OPA and CT, but not between IOP measurements and CT. Choroidal thickness and OPA tended to increase approximately 15 minutes before the IOP rise. These findings bring helpful information on the understanding of this stress test. During the Water Drinking Test there is a transient intraocular pressure rise followed by an increase in the Ocular Pulse Amplitude and choroidal thickness
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