May 2008
Volume 49, Issue 13
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ARVO Annual Meeting Abstract  |   May 2008
Glaucomatous Progression Detection by Perimetry Using Visual Field Index (VFI) and Global Parameters
K. Sung; G. Wollstein; H. Ishikawa; R. A. Bilonick; K. A. Townsend; L. Kagemann, Jr.; V. Jurisic; R. J. Noecker; M. L. Gabriele; J. S. Schuman
Author Affiliations & Notes
  • K. Sung
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • G. Wollstein
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • H. Ishikawa
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Dept. of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania
  • R. A. Bilonick
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • K. A. Townsend
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • L. Kagemann, Jr.
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Dept. of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania
  • V. Jurisic
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • R. J. Noecker
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • M. L. Gabriele
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Dept. of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania
  • J. S. Schuman
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Dept. of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania
  • Footnotes
    Commercial Relationships  K. Sung, None; G. Wollstein, Carl Zeiss Meditec Inc., Optovue, F; H. Ishikawa, None; R.A. Bilonick, None; K.A. Townsend, None; L. Kagemann, None; V. Jurisic, None; R.J. Noecker, Alcon; Allergan; Merck; Heidelberg Engineering; Lumenis, R; M.L. Gabriele, None; J.S. Schuman, Alcon; Allergan; Carl Zeiss Meditec, Inc.; Merck; Optovue; Heidelberg Engineering, F; Carl Zeiss Meditec, Inc., P; Alcon; Allergan; Carl Zeiss Meditec, Inc.; Merck; Heidelberg Engineering, Optovue, R.
  • Footnotes
    Support  NIH R01-EY013178-8, P30-EY008098; Eye and Ear Foundation (Pittsburgh, PA); Research to Prevent Blindness.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1091. doi:
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      K. Sung, G. Wollstein, H. Ishikawa, R. A. Bilonick, K. A. Townsend, L. Kagemann, Jr., V. Jurisic, R. J. Noecker, M. L. Gabriele, J. S. Schuman; Glaucomatous Progression Detection by Perimetry Using Visual Field Index (VFI) and Global Parameters. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1091.

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Abstract
 
Purpose:
 

Visual field index (VFI), a new parameter representing global sensitivity, is based on location weighted average of pattern deviation depression at 5% or worse compared to age matched normal values, with values ranging from 0% for no response to light to 100% for values at the level of the age matched normals. The purpose of this study was to assess the performance of VFI and global perimetry parameters on glaucomatous progression detection.

 
Methods:
 

Sixty-two subjects with glaucoma (90 eyes) and glaucoma suspects (20 eyes) with at least 5 reliable visual fields (VF) were analyzed. Four global parameters were recorded: VFI, mean deviation (MD), pattern standard deviation (PSD) and advanced glaucoma intervention study (AGIS) score. A latent class regression (LCR) model was used to define glaucoma progressors and nonprogressors. Each parameter was transformed to have a mean of zero and a standard deviation of one to place all measures on the same scale. The slopes for each parameter and measurement error standard deviations (SD) were calculated for each latent group during the period of follow-up. The measurement error provides an estimate on the repeatability of the measurements over time. The prediction of progression by baseline measurement was assessed by the area under the receiver operating characteristics curve (AUC).

 
Results:
 

The LCR model categorized 36 eyes as latent progressors and 74 eyes as latent non-progressors. The table summarizes the slope and measurement error SD for each parameter in the progressors and the non-progressors groups.  

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Conclusions:
 

VFI as well as all other parameters showed similar slope and measurement error over time. AGIS score had the overall best performance among the tested parameters though slightly lower prediction ability due to lower AUC compared to the other parameters.

 
Clinical Trial:
 

www.clinicaltrials.gov NCT00286637

 
Keywords: visual fields 
© 2008, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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