May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Motion Hyperacuity in Glaucoma: Comparison of the Extent of Damage Identified With the Moorfields Motion Displacement Test (MDT) with Standard Automated Perimetry
Author Affiliations & Notes
  • G. M. Verdon-Roe
    Glaucoma Research Unit, Moorfields Eye Hospital, London, United Kingdom
    Institute of Ophthalmology, UCL, London, United Kingdom
  • R. Moosavi
    Institute of Ophthalmology, UCL, London, United Kingdom
    City University, London, United Kingdom
  • C. Bergin
    City University, London, United Kingdom
  • M. C. Westcott
    Institute of Ophthalmology, UCL, London, United Kingdom
    St Bartholomew's Hospital, London, United Kingdom
  • D. P. Crabb
    City University, London, United Kingdom
  • A. C. Viswanathan
    Glaucoma Research Unit, Moorfields Eye Hospital, London, United Kingdom
    Institute of Ophthalmology, UCL, London, United Kingdom
  • F. W. Fitzke
    Institute of Ophthalmology, UCL, London, United Kingdom
  • D. F. Garway-Heath
    Glaucoma Research Unit, Moorfields Eye Hospital, London, United Kingdom
    Institute of Ophthalmology, UCL, London, United Kingdom
  • Footnotes
    Commercial Relationships  G.M. Verdon-Roe, Pfizer, F; Moorfields MDT, P; R. Moosavi, Pfizer, F; C. Bergin, None; M.C. Westcott, Pfizer, F; Moorfields MDT, P; D.P. Crabb, None; A.C. Viswanathan, Pfizer, F; Moorfields MDT, P; F.W. Fitzke, Moorfields MDT, P; D.F. Garway-Heath, Carl Zeiss Meditec, F; Heidelberg Engineering, F; Moorfields MDT, P; Carl Zeiss Meditec, R.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1156. doi:https://doi.org/
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      G. M. Verdon-Roe, R. Moosavi, C. Bergin, M. C. Westcott, D. P. Crabb, A. C. Viswanathan, F. W. Fitzke, D. F. Garway-Heath; Motion Hyperacuity in Glaucoma: Comparison of the Extent of Damage Identified With the Moorfields Motion Displacement Test (MDT) with Standard Automated Perimetry. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1156. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To compare the extent of damage mapped by, and the dynamic range of, the Moorfields Motion displacement test (MDT) and Standard Automated perimetry (SAP). The MDT is a new hyperacuity test for the detection of glaucoma. There are 32 line stimuli, each scaled by age and eccentricity and corresponding to a Humphrey 24-2 location. The MDT runs on a standard computer and has been shown to be more robust to the effects of media opacity and refractive blur than SAP.

 
Methods:
 

One eye of 40 glaucoma patients (23 POAG; 12 NTG; 5 PDS; mean age 65, range 34 to 82 years), with abnormal HRT Moorfields regression and reproducible SAP loss (average mean defect: -5.24, range -8.80 to 0.59 dB), underwent MDT and SAP (SITA standard). MDT probability values were generated from 120 aged-match controls. Locations with thresholds at P< 5% for either or both MDT and SAP were compared point-wise for total deviation (TD) and pattern deviation (PD) plots.

 
Results:
 

The MDT identified field defects (≥2 contiguous points in the same hemifield) in all subjects. Of locations abnormal by either MDT or SAP: 70 % (TD) and 70% (PD) were abnormal by both; 11% (TD) and 8 % (PD) by SAP alone; 19% (TD) and 23% (PD) by MDT alone. There were significantly more locations abnormal by MDT than SAP (Wilcoxon P<0.01). The dynamic range of the MDT (0-22 min arc displacement) corresponded to 22-32 dB measured with SAP.

 
Conclusions:
 

The Moorfields MDT is a promising new test for the detection of glaucoma, showing topographical correspondence with SAP and evidence that the field loss identified by MDT is more extensive than that identified by SAP.Plot illustrating the dynamic ranges of SAP (dB) and MDT (min arc).  

 
Keywords: perimetry 
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