May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Retinal Arteriolar Narrowing Predicts Incidence of Diabetes:The Australian Diabetes, Obesity and Lifestyle (AusDiab) Study
Author Affiliations & Notes
  • T. T. Nguyen
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
  • J. Wang
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
    Centre for Vision Research, University of Sydney, Sydney, Australia
  • F. Islam
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
  • P. Mitchell
    Centre for Vision Research, University of Sydney, Sydney, Australia
  • P. Zimmet
    International Diabetes Institute, Melbourne, Australia
  • R. Simpson
    Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
  • J. Shaw
    International Diabetes Institute, Melbourne, Australia
  • T. Y. Wong
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
    Singapore Eye Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
  • Footnotes
    Commercial Relationships  T.T. Nguyen, None; J. Wang, None; F. Islam, None; P. Mitchell, None; P. Zimmet, None; R. Simpson, None; J. Shaw, None; T.Y. Wong, None.
  • Footnotes
    Support  NH&MRC grants 350448 and 233200, and a Sylvia and Charles Viertel Charitable Foundation grant
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1165. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      T. T. Nguyen, J. Wang, F. Islam, P. Mitchell, P. Zimmet, R. Simpson, J. Shaw, T. Y. Wong; Retinal Arteriolar Narrowing Predicts Incidence of Diabetes:The Australian Diabetes, Obesity and Lifestyle (AusDiab) Study. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1165. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : To examine the relationship of retinal vascular caliber to incident diabetes in a population-based cohort.

Methods: : The Australian Diabetes, Obesity and Lifestyle Study recruited adults aged 25+ years across Australia in 1999-2000, with a follow up 5 years later in 2004-2005. Participants’ glycemic status was classified using fasting plasma glucose (FPG) and 2-hour oral glucose tolerance (2hPG) tests. Diabetes was diagnosed if FPG ≥7.0 mmol/l or 2hPG ≥11.1mmol/l. Retinal vascular caliber was measured from baseline retinal photographs using a computer-assisted program.

Results: : Of the 803 participants without diabetes at baseline, 108 (13.4%) developed diabetes at follow up: 7 (2.8%) from 246 participants with normal glucose tolerance, 9 (13.6%) from 66 participants with impaired fasting glucose, and 92 (18.7%) from 491 participants with impaired glucose tolerance. After multivariate analysis, participants with narrower retinal arteriolar caliber had higher risk of diabetes (odds ratio 2.37, 95% confidence interval 1.14-4.91, comparing smallest vs. highest arteriolar caliber tertiles, p=0.02 for trend). There was no association between retinal venular caliber and incident diabetes.

Conclusions: : Narrower retinal arteriolar caliber predicted risk of diabetes. These data provide further evidence that microvascular changes may contribute to the pathogenesis of diabetes.

Keywords: diabetes • retina • imaging/image analysis: non-clinical 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×