May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Visual Contrast Sensitivity Assessment in Early Stages of Alzheimer's Disease: A Preliminary Study Using Frequency Doubled Technology
Author Affiliations & Notes
  • S. M. Pepin
    Dartmouth Hitchcock Medical Ctr, Lebanon, New Hampshire
    Ophthalmology,
  • A. Saykin
    Radiology, Indiana University School of Medicine, Indianapolis, Indiana
  • H. A. Wishart
    Dartmouth Hitchcock Medical Ctr, Lebanon, New Hampshire
    Psychiatry,
  • R. Santulli
    Dartmouth Hitchcock Medical Ctr, Lebanon, New Hampshire
    Psychiatry,
  • R. Newman
    Welch Allyn, Skaneateles Falls, New York
  • Footnotes
    Commercial Relationships  S.M. Pepin, None; A. Saykin, None; H.A. Wishart, None; R. Santulli, None; R. Newman, Welch Allyn, E.
  • Footnotes
    Support  Welch Allyn
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1194. doi:https://doi.org/
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    • Get Citation

      S. M. Pepin, A. Saykin, H. A. Wishart, R. Santulli, R. Newman; Visual Contrast Sensitivity Assessment in Early Stages of Alzheimer's Disease: A Preliminary Study Using Frequency Doubled Technology. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1194. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : The goal of this study was to gain pilot data on whether the Welch Allyn Frequency Doubling Technology (FDT2 model) is sensitive to early/preclinical stages of Alzheimer’s disease (AD).

Methods: : A cross-sectional study design was employed to compare the FDT test variables between healthy controls, mild AD patients and amnestic AD patients. 6 mild AD patients, 6 amnestic MCI patients and 6 healthy controls were recruited for the study. After exclusions and re-testing, 5 patients with early AD, 4 patients with amnestic MCI and 5 healthy demographically comparable older controls. Many participants were examined twice to address technical issues and confirm initial results.

Results: : The FDT2 data were analyzed independently by two groups. Analysis by one statistician indicated that several variables appeared promising as discriminators of the three diagnostic groups (AD, MCI, HC-healthy controls): AD v. HC: test time (p=0.0031), peripheral/central (p=0.0034), mean deviation (average loss of entire field) (p=0.0118), and pattern standard deviation (irregularity in visual field) (p=0.0128).

Conclusions: : The variables of average loss of entire visual field, irregularity in the visual field and test taking time appear promising as discriminators of AD, MCI and HC. A further phase of the study will increase the number of participants to be sufficient for multivariate analysis. It was determined that in the next phase of the study a sample of 30 HC, 30 MCI, and 30 early AD would be sufficient for multivariate analysis combining these or other FDT2 features as predictors of class membership.

Keywords: visual impairment: neuro-ophthalmological disease • visual fields 
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