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M. T. Balenga, J.-C. Mwanza; On Two Rare Cases of Ethambutol-Associated Optic Chiasmopathy. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1200.
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To report two cases of ETB-associated optic neuropathy that ultimately progessed to optic chiasmopathy, and to discuss the possible mechanism of its occurrence.
All two patients were first dignosed with bilateral optic neuropathy while being treated with ETB at normal therapeutic doses. Although treatment was discontinued the disease inexorably progressed to optic chiasmopathy.
With ETB still being the first-line drug to control tuberculosis around the world, it is important to be aware that toxic optic chiasmopathy may develop, expecially if optic neuropathy does not improve after discontinuation of treatment.
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