May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Aceclidine, Brimonidine Tartrate 0.2% and Dapiprazole:A Comparison for Miotic Effect and Tolerability Under Different Lightning Conditions
Author Affiliations & Notes
  • A. Canovetti
    Ophthalmology, University of Pisa, Pisa, Italy
  • M. Figus
    Ophthalmology, University of Pisa, Pisa, Italy
  • U. Benelli
    Ophthalmology, University of Pisa, Pisa, Italy
  • P. Fogagnolo
    G.B.Bietti Foundation for Study and Research in Ophthalmology, Rome, Italy
  • M. Nardi
    Ophthalmology, University of Pisa, Pisa, Italy
  • Footnotes
    Commercial Relationships  A. Canovetti, None; M. Figus, None; U. Benelli, None; P. Fogagnolo, None; M. Nardi, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1208. doi:https://doi.org/
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      A. Canovetti, M. Figus, U. Benelli, P. Fogagnolo, M. Nardi; Aceclidine, Brimonidine Tartrate 0.2% and Dapiprazole:A Comparison for Miotic Effect and Tolerability Under Different Lightning Conditions. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1208. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To evaluate the effect on pupil diameter of three different miotic eye-drops: aceclidine, brimonidine tartrate 0.20% and dapiprazole, when applied topically in normal subjects

 
Methods:
 

The eyes of 30 healthy volunteers were included in this study. Pupil diameter was measured under scotopic, mesopic (4 lux) and photopic (50 lux) conditions, using an infrared pupillometer, in conjunction with a CSOTM topographer. The first measurement was obtained before the sole instillation of the three different kinds of eye drops. Afterwards, measurements were performed after 30, 120 and 240 minutes. Each additional eye medication was tested further after at least a 10 day interval in order to avoid any possible drug interference. Every patient received a questionnaire to grade the tolerability of each kind of eye drops by a subjective scoring system.

 
Results:
 

Aceclidine had an unimportant miotic effect. Brimonidine caused significant miosis within 30 and 120 minutes: then the effect reduced without reaching the initial baseline at the forth hour in all different luminance conditions. Dapiprazole had a quite similar miotic effect to brimonidine but it produced many side effects, including hyperemia and burning, which caused too much discomfort for most of patients.  

 
Conclusions:
 

Brimonidine tartrate 0.20% seems to have the best miotic effect together with good patient tolerability in comparison with aceclidine and dapiprazole. The reproducible miotic effect of this eye drop under all lighting conditions might help postoperative refractive patients who report night-vision difficulties related with large pupils.

 
Keywords: refractive surgery • pupil 
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