May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
24-Hour Intraocular Pressure Control With the Travoprost/Timolol Fixed Combination Compared With Travoprost When Both Are Dosed in the Evening in Primary Open-Angle Glaucoma
Author Affiliations & Notes
  • D. Mikropoulos
    1st University, Thessaloniki, Greece
  • A. G. P. Konstas
    1st University, Thessaloniki, Greece
  • B. Haidich
    Aristotle University, Thessaloniki, Greece
  • K. S. Ntampos
    1st University, Thessaloniki, Greece
  • W. C. Stewart
    University of South Carolina, Columbia, South Carolina
  • Footnotes
    Commercial Relationships  D. Mikropoulos, None; A.G.P. Konstas, None; B. Haidich, None; K.S. Ntampos, None; W.C. Stewart, None.
  • Footnotes
    Support  Unrestricted grant from Alcon Research
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1212. doi:https://doi.org/
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      D. Mikropoulos, A. G. P. Konstas, B. Haidich, K. S. Ntampos, W. C. Stewart; 24-Hour Intraocular Pressure Control With the Travoprost/Timolol Fixed Combination Compared With Travoprost When Both Are Dosed in the Evening in Primary Open-Angle Glaucoma. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1212. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Methods: : This study was a prospective, double-masked, crossover, active-controlled, randomized comparison. Following a 6-week washout, patients were randomized to the travoprost/timolol fixed combination or travoprost for 8 weeks. Patients were then switched to the opposite treatment for 8 weeks. At the end of the washout and treatment periods a 24-hour intraocular pressure (IOP) curve was performed.

Results: : In total, 34 patients were enrolled of whom 32 completed. One patient was discontinued from the fixed combination because of ocular intolerance and the other from travoprost due to headaches and gastro-intestinal disturbance. The fixed combination group demonstrated a lower absolute IOP, and greater reduction from untreated baseline, than travoprost for the 24-hour curve and at each time point (P<0.047). Further, the mean 24-hour IOP fluctuation was lower with fixed combination therapy (3.0 mmHg) compared to travoprost (4.0 mmHg, P = 0.001). Additionally, the mean maximum and mean minimum IOPs were less with the fixed combination (P<0.001, for both comparisons). No statistical difference existed between the two treatment groups for any adverse event. The most common adverse event was conjunctival hyperemia which was found in 24% (n=8) of patients treated with travoprost and 15% (n = 5) for the fixed combination (P = 0.25).

Conclusions: : This study suggests that when both drugs are dosed in the evening the travoprost/timolol fixed combination provides improved IOP reduction over the 24-hour curve and for each individual time point in primary open-angle glaucoma patients.

Clinical Trial: : www.clinicaltrials.gov NCT00444184

Keywords: intraocular pressure • drug toxicity/drug effects • clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials 
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