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J. M. Davis, S. S. Samudre, B. R. Martin, F. A. Lattanzio, Jr., E. R. Crouch, Jr., P. B. Williams; Effects of Cannabinoids on Intraocular Pressure When Added in Combination With Timolol, Dorzolamide or Brimonidine in a Rat Glaucoma Model. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1213.
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Surgical ligation of three of the four episcleral veins in one eye of Sprague Dawley rats caused a sustained (>44 wk) IOP increase. IOP was measured by TonolabTM at baseline and after 30, 60 and 120 min, as was heart rate and blood pressure. For combination therapy, after baseline IOP measurement, timolol 0.5%, brimonidine 0.1% or dorzolamide 2.0% was applied topically followed 10 min later by O-1812 1.0%, or O-2545 1.0%. An assessment for ocular irritation was performed by slit lamp examination at baseline and after 120 min.
Compared to baseline, within 30 min all drugs and combinations significantly decreased IOP (p<0.05). Among the single drug regimen, O-1812 and dorzolamide had the greatest effect at 30 min. All, except brimonidine, maintained a significant IOP reduction for up to 120 min. No additive effects were seen with combination therapy. Both timolol and dorzolamide actually decreased the effect of O-1812. Timolol also decreased the effect of O-2545. No drug alone or in combination caused ocular irritation or systemic effects.
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