May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Can CCT and Its Fluctuations Influence the Amount of Circadian Intraocular Pressure Fluctuations?
Author Affiliations & Notes
  • P. Fogagnolo
    G.B. Bietti Foudation – IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Rome, Italy
  • F. Capizzi
    Eye Clinic, Department of Medicine, Surgery and Odontoiatry, San Paolo Hospital, University of Milan, Milan, Italy
  • L. Rossetti
    Eye Clinic, Department of Medicine, Surgery and Odontoiatry, San Paolo Hospital, University of Milan, Milan, Italy
  • M. Figus
    Eye Clinic, University of Pisa, Pisa, Italy
  • A. Ferreras
    Miguel Servet University Hospital, Zaragoza, Spain
  • N. Orzalesi
    Eye Clinic, Department of Medicine, Surgery and Odontoiatry, San Paolo Hospital, University of Milan, Milan, Italy
  • Footnotes
    Commercial Relationships  P. Fogagnolo, None; F. Capizzi, None; L. Rossetti, None; M. Figus, None; A. Ferreras, None; N. Orzalesi, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 691. doi:https://doi.org/
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      P. Fogagnolo, F. Capizzi, L. Rossetti, M. Figus, A. Ferreras, N. Orzalesi; Can CCT and Its Fluctuations Influence the Amount of Circadian Intraocular Pressure Fluctuations?. Invest. Ophthalmol. Vis. Sci. 2008;49(13):691. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate the influence of central corneal thickness (CCT) and its 24-hr fluctuations on nicthoemeral intraocular pressure (IOP) fluctuations in glaucoma subjects.

Methods: : 36 consecutive patients (age: 67±8 years; F/M=17/19) with primary open-angle glaucoma underwent circadian evaluation (8 pm, midnight, 4 am, 8 am, noon, and 4 pm) of supine and sitting IOP, measured with a handheld Perkins and a Goldmann tonometer respectively, and of CCT measured using an ultrasonic pachymeter. 30 patients were treated with timolol 0.5% twice daily (8 am, 8 pm) and latanoprost 0.005% once daily (9 pm); 6 patients were untreated. Individual fluctuations were calculated as the standard deviation over the 24-hr curves. The correlations between CCT and its fluctuations and IOP fluctuations were evaluated by means of regression analysis.

Results: : The correlation between mean CCT and CCT fluctuations and IOP fluctuations was not statistically significant both at supine (y=6.38, P=0.92 and y=-0.04x+7.66, P=0.57 respectively) and sitting position (y=0.02x-5.61, P=0.06 and y=-0.04x+5.92, P=0.51). No differences were found between treated and untreated patients (P=0.27).

Conclusions: : In the present study, 24-hr IOP fluctuations were independent from mean CCT values and their 24-hr fluctuations both in treated and untreated glaucoma patients.

Keywords: circadian rhythms 
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