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P. Fogagnolo, F. Capizzi, L. Rossetti, M. Figus, A. Ferreras, N. Orzalesi; Can CCT and Its Fluctuations Influence the Amount of Circadian Intraocular Pressure Fluctuations?. Invest. Ophthalmol. Vis. Sci. 2008;49(13):691.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the influence of central corneal thickness (CCT) and its 24-hr fluctuations on nicthoemeral intraocular pressure (IOP) fluctuations in glaucoma subjects.
36 consecutive patients (age: 67±8 years; F/M=17/19) with primary open-angle glaucoma underwent circadian evaluation (8 pm, midnight, 4 am, 8 am, noon, and 4 pm) of supine and sitting IOP, measured with a handheld Perkins and a Goldmann tonometer respectively, and of CCT measured using an ultrasonic pachymeter. 30 patients were treated with timolol 0.5% twice daily (8 am, 8 pm) and latanoprost 0.005% once daily (9 pm); 6 patients were untreated. Individual fluctuations were calculated as the standard deviation over the 24-hr curves. The correlations between CCT and its fluctuations and IOP fluctuations were evaluated by means of regression analysis.
The correlation between mean CCT and CCT fluctuations and IOP fluctuations was not statistically significant both at supine (y=6.38, P=0.92 and y=-0.04x+7.66, P=0.57 respectively) and sitting position (y=0.02x-5.61, P=0.06 and y=-0.04x+5.92, P=0.51). No differences were found between treated and untreated patients (P=0.27).
In the present study, 24-hr IOP fluctuations were independent from mean CCT values and their 24-hr fluctuations both in treated and untreated glaucoma patients.
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