May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Within and Between Trial Repeatability of Pattern Electroretinogram Optimized for Glaucoma Detection (PERGLA)
Author Affiliations & Notes
  • A. Tafreshi
    Hamilton Glaucoma Center, Dept. of Ophthalmology, University of California, San Diego, La Jolla, California
  • G. Vizzeri
    Hamilton Glaucoma Center, Dept. of Ophthalmology, University of California, San Diego, La Jolla, California
  • R. N. Weinreb
    Hamilton Glaucoma Center, Dept. of Ophthalmology, University of California, San Diego, La Jolla, California
  • L. M. Zangwill
    Hamilton Glaucoma Center, Dept. of Ophthalmology, University of California, San Diego, La Jolla, California
  • P. A. Sample
    Hamilton Glaucoma Center, Dept. of Ophthalmology, University of California, San Diego, La Jolla, California
  • C. Bowd
    Hamilton Glaucoma Center, Dept. of Ophthalmology, University of California, San Diego, La Jolla, California
  • Footnotes
    Commercial Relationships  A. Tafreshi, None; G. Vizzeri, None; R.N. Weinreb, Carl Zeiss Meditec, F; Heidelberg Engineering, F; Carl Zeiss Meditec, C; L.M. Zangwill, Carl Zeiss Meditec, F; Heidelberg Engineering, F; Optovue, F; P.A. Sample, Carl Zeiss Meditec, F; Haag Streit, F; Welch-Allyn, F; C. Bowd, Lace Elettronica, F.
  • Footnotes
    Support  NIH EY008208, NIH EY011008, NIH EY018190, Participant incentive grants in the form for medication at no cost: Alcon, Allergan, Pfizer, Santen
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 721. doi:https://doi.org/
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    • Get Citation

      A. Tafreshi, G. Vizzeri, R. N. Weinreb, L. M. Zangwill, P. A. Sample, C. Bowd; Within and Between Trial Repeatability of Pattern Electroretinogram Optimized for Glaucoma Detection (PERGLA). Invest. Ophthalmol. Vis. Sci. 2008;49(13):721. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To determine the within and between trial repeatability of pattern electroretinogram measurements in healthy eyes, using a new clinical instrument, the PERGLA (Glaid, Lace Elettronica, Pisa, Italy).

Methods: : 70 eyes of 35 healthy individuals (IOP < 22 mm Hg, healthy optic disc by stereophotograph assessment, standard visual fields within normal limits) enrolled in the UCSD Diagnostic Innovations in Glaucoma Study (DIGS) (mean age = 61.3, S.D. = 9.7 years, 27 female) were tested twice by a single operator using the PERGLA device. All eyes were refracted and near acuity was J1 for all participants. Repeatability of measurements between two runs within a single trial was compared to repeatability of measurements between two trials (i.e., after electrode replacement) by calculating the coefficients of variability (CVs) and the intraclass correlation coefficients (ICCs).

Results: : Average (S.D.) amplitude, phase and signal-to-noise ratio were 0.80 (0.26), 1.81 (0.11) and 5.7 (3.15), respectively. CVs (ICCs) were 11.0% (0.87) and 1.5% (0.89), and 10.2% (0.84) and 1.8% (0.78) for amplitude and phase for within and between trial measurements, respectively. Bland-Altman plots indicated good agreement between the measurements and were similar within and between trials (95% limits of agreement between trials were -0.26 and 0.31 for the amplitude and -0.13 and 0.19 for the phase). 12 eyes of 8 individuals were outside of normal limits based on amplitude and/or phase, as determined by the instrument's internal normative database.

Conclusions: : Repeatability of PERGLA measurements is good and is very similar within and between trials, suggesting this technique is promising for monitoring change over time (e.g., little effect of electrode replacement). However, based on previous studies, variability likely is greater in glaucoma patients. Specificity of the normative database was moderate in this population.

Keywords: electroretinography: clinical 
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