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K. Baba, E. Asano, A. Sawada, K. Mochizuki, T. Yamamoto; The Association With Nasal-Temporal Asymmetry Of The Second Order Kernel Response of Multifocal Electroretinogram and Morphological and Functional Parameters in Glaucoma. Invest. Ophthalmol. Vis. Sci. 2008;49(13):725.
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© ARVO (1962-2015); The Authors (2016-present)
To explore relationships between functional parameters obtained from multifocal electroretinogram (mfERG) and Humphrey Field Analyzer (HFA), and structural parameters by Heidelberg Retina Tomograph (HRTII) in glaucoma patients.
MfERGs of 25 normal volunteers and 30 open-angle glaucoma patients were recorded. The glaucoma patients also were evaluated with HFA, and HRTII. All tests were performed within 6 months of each other. In glaucoma patients, they were assigned into three subgroups based on a level of mean deviation (MD) obtained from HFA using the central 30-2 program (i.e. Group 1: -5 dB < MD, Group 2: -10 dB < MD < -5 dB, Group 3: MD < -10 dB). The relationships among the parameters obtained from mfERG, HRTII parameters, and visual field indexes were analyzed by coefficients and linear regression analysis.
The amplitude ratio in the nasal to temporal hemisphere of the second order kernel response within the central 5° (N/T ratio) was 0.64 ± 0.14, 0.80 ± 0.16, 0.83 ± 0.15, and 0.96±0.14 in the normals, Group 1, Group 2, and Group 3, respectively. There was a statistically significant difference among the 4 groups (P < 0.0001; ANOVA). Additionally, the mfERG parameter showed significant correlations with MD (r2=0.209, P= 0.0248) and pattern standard deviation (r2=0.25, P= 0.0051). However, any global and sectoral HRT II parameters failed to correlate with N/T ratio.
Decrease in the nasal-temporal asymmetry in amplitude of the second order kernel responses within the central 5° might reflect functional damage more than morphological change in glaucoma.
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