May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
The Association With Nasal-Temporal Asymmetry Of The Second Order Kernel Response of Multifocal Electroretinogram and Morphological and Functional Parameters in Glaucoma
Author Affiliations & Notes
  • K. Baba
    Ophthalmology, Gifu Univ Grad Sch of Medicine, Gifu, Japan
  • E. Asano
    Ophthalmology, Gifu Univ Grad Sch of Medicine, Gifu, Japan
  • A. Sawada
    Ophthalmology, Gifu Univ Grad Sch of Medicine, Gifu, Japan
  • K. Mochizuki
    Ophthalmology, Gifu Univ Grad Sch of Medicine, Gifu, Japan
  • T. Yamamoto
    Ophthalmology, Gifu Univ Grad Sch of Medicine, Gifu, Japan
  • Footnotes
    Commercial Relationships  K. Baba, None; E. Asano, None; A. Sawada, None; K. Mochizuki, None; T. Yamamoto, None.
  • Footnotes
    Support  Grant-in-Aid for scientific research from Ministry of Education, Culture, Sports, Science and Technology of Japan (1779122703)
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 725. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      K. Baba, E. Asano, A. Sawada, K. Mochizuki, T. Yamamoto; The Association With Nasal-Temporal Asymmetry Of The Second Order Kernel Response of Multifocal Electroretinogram and Morphological and Functional Parameters in Glaucoma. Invest. Ophthalmol. Vis. Sci. 2008;49(13):725. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : To explore relationships between functional parameters obtained from multifocal electroretinogram (mfERG) and Humphrey Field Analyzer (HFA), and structural parameters by Heidelberg Retina Tomograph (HRTII) in glaucoma patients.

Methods: : MfERGs of 25 normal volunteers and 30 open-angle glaucoma patients were recorded. The glaucoma patients also were evaluated with HFA, and HRTII. All tests were performed within 6 months of each other. In glaucoma patients, they were assigned into three subgroups based on a level of mean deviation (MD) obtained from HFA using the central 30-2 program (i.e. Group 1: -5 dB < MD, Group 2: -10 dB < MD < -5 dB, Group 3: MD < -10 dB). The relationships among the parameters obtained from mfERG, HRTII parameters, and visual field indexes were analyzed by coefficients and linear regression analysis.

Results: : The amplitude ratio in the nasal to temporal hemisphere of the second order kernel response within the central 5° (N/T ratio) was 0.64 ± 0.14, 0.80 ± 0.16, 0.83 ± 0.15, and 0.96±0.14 in the normals, Group 1, Group 2, and Group 3, respectively. There was a statistically significant difference among the 4 groups (P < 0.0001; ANOVA). Additionally, the mfERG parameter showed significant correlations with MD (r2=0.209, P= 0.0248) and pattern standard deviation (r2=0.25, P= 0.0051). However, any global and sectoral HRT II parameters failed to correlate with N/T ratio.

Conclusions: : Decrease in the nasal-temporal asymmetry in amplitude of the second order kernel responses within the central 5° might reflect functional damage more than morphological change in glaucoma.

Keywords: clinical research methodology • electroretinography: clinical • imaging/image analysis: clinical 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×