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H. Nomoto, C. Matsumoto, S. Okuyama, S. Takada, S. Hashimoto, F. Tanabe, E. Arimura, Y. Shimomura; Relationship Between Functional and Structural Changes Tested by SAP, FDT, Flicker Perimetry, SWAP and OCT in Glaucoma. Invest. Ophthalmol. Vis. Sci. 2008;49(13):730.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the relationship between the abnormalities with each test location for SAP, FDT, flicker perimetry, SWAP and the 12 clock-hour sectors of retinal nerve fiber layer (RNFL) thickness as measured by OCT in patients with glaucoma and glaucoma suspected (GS).
Eighty-four eyes of 84 subjects with glaucoma and GS were enrolled in this cross-sectional study. All subjects underwent HFA 24-2 full threshold (SAP), FDT (24-2-5, 24-2-1), flicker perimetry (4-zone 38S) using Octopus 311, SITA-SWAP and OCT (fast RNFL thickness). Glaucoma patients were divided into early, moderate and advanced stages by mean deviation (MD) of SAP result. Each test location of 52 test points was estimated by 3 grades (normal, 5% and 1% abnormality level) for SAP, FDT, flicker perimetry and SWAP, and each sector of the RNFL thickness was graded into 3 levels (normal, 5% and 1% abnormality level of inbuilt normative database with OCT software) also. For each test location, which RNFL sectors had the relationship between variables were evaluated.
In all subjects (mean MD, -3.42±3.01 dB), SAP test locations in the superior and inferior hemifield were significantly related to 6, 7, 8, 10 clock-hour sectors and 1, 8, 10, 11, 12 clock-hour sectors (P < 0.001: Chi-square test and Spearman’s rank correlation coefficient), respectively. For the superior hemifield, 7, 8 clock-hour sectors had good relationship to almost all locations and 6 clock-hour sector related to peripheral locations. For the inferior hemifield, 10, 11 clock-hour sectors mainly related to central locations and 12 clock-hour sector related to peripheral locations. In subjects with early stage glaucoma and GS (mean MD, -1.82±1.41 dB), SAP, FDT, flicker perimetry and SWAP results in the superior and inferior hemifield were significantly related to 6, 7, 8 clock-hour sectors and 9, 10, 11, 12 clock-hour sectors (P < 0.01: Chi-square test, P < 0.05: Spearman’s rank correlation coefficient), respectively. FDT, flicker perimetry and SWAP results had more related locations to RNFL sectors than SAP results.
Functional changes with test locations relate to structural changes with the anatomically corresponded RNFL sectors. Moreover, the earlier functional changes with test locations which are detected by FDT, flicker perimetry and SWAP relate to the decrease of RNFL thickness in particular sectors.
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