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D. Nelson, M. D. Abramoff, Y. H. Kwon, E. C. Greenlee, W. L. M. Alward, C. A. Johnson; Correlation of Progression Between Structure and Function in Ocular Hypertensive Patients From the SAFE Study. Invest. Ophthalmol. Vis. Sci. 2008;49(13):738. doi: https://doi.org/.
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To quantitatively measure the relationship between functional and structural progression in ocular hypertension.
Longitudinal data sets (of ≥3 year follow-up) of simultaneous stereo optic disc photographs (Nidek 3Dx) and Humphrey visual fields (Standard Automated Perimetry (SAP) & Short-Wavelength Automated Perimetry (SWAP)) were obtained from 107 eyes of 107 ocular hypertensive patients from the Structure And Function Evaluation (SAFE) study (Johnson CA et al. AJO 134:177, 2002). The current study patients were chosen from the UC Davis cohort based on availability of both disc photographs and HVF with ≥3 consecutive years of follow-up. Structural progression was quantified using the linear cup-to-disc ratio (LCDR) obtained from computer-aided planimetry by three glaucoma experts on digitized stereo photographs. Functional progression was quantified using the sensitivity data (linear and logarithmic) from SAP and SWAP. Pearson correlation (r2) values were found for each best-fit linear regression of structure and function progression both globally and sectorally.
The average baseline values and Pearson r2 correlations for the HVF versus LCDR progressions are summarized in Table 1. No significant correlation was found between LCDR and either SAP or SWAP sensitivity progressions in this cohort. The best correlation was found between the SWAP sensitivity progression versus LCDR progression in the inferior-temporal sector (r2 = 0.033). No improvement occurred when using sectoral data versus global data.
In these ocular hypertensive eyes, no significant correlation was found between LCDR and HVF change over the 3 year period. However, the (average) absolute change in LCDR (+0.001) as well as SAP (-0.499 dB) and SWAP (-0.785 dB) were small. Longer follow-up with a greater amount of structural and functional progression may reveal better correlation.
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