May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Normal versus High Tension Glaucoma: A Comparison of Functional and Structural Deficits
O. Thonginnetra; V. C. Greenstein; D. Chu; J. M. Liebmann; R. Ritch; D. C. Hood
Author Affiliations & Notes
  • O. Thonginnetra
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York
  • V. C. Greenstein
    Ophthalmology, Columbia University, New York, New York
    NYU School of Medicine, New York, New York
  • D. Chu
    Ophthalmology, Baylor College of Medicine, Houston, Texas
  • J. M. Liebmann
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York
    NYU School of Medicine, New York, New York
  • R. Ritch
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York
    New York Medical College, Valhalla, New York
  • D. C. Hood
    Ophthalmology, Columbia University, New York, New York
  • Footnotes
    Commercial Relationships  O. Thonginnetra, None; V.C. Greenstein, None; D. Chu, None; J.M. Liebmann, None; R. Ritch, None; D.C. Hood, None.
  • Footnotes
    Support  NIH Grant EY02115, Supported in part by Corinne Graber Research Fund of The New York Glaucoma Research Institute, New York, NY
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 744. doi:
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      O. Thonginnetra, V. C. Greenstein, D. Chu, J. M. Liebmann, R. Ritch, D. C. Hood; Normal versus High Tension Glaucoma: A Comparison of Functional and Structural Deficits. Invest. Ophthalmol. Vis. Sci. 2008;49(13):744.

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Abstract

Purpose: : To compare visual field deficits measured with multifocal visual evoked potential (mfVEP) and Humphrey visual field (HVF) techniques to measurements of optic disc topography in patients with normal tension glaucoma (NTG) and high tension glaucoma (HTG).

Methods: : Thirty patients with NTG and 32 with HTG were studied. All patients had reliable 24-2 HVFs with a mean deviation (MD) ≥-10 dB and a glaucomatous optic disc and an abnormal HVF (PSD and/or GHT) in at least one eye. Monocular mfVEPs were obtained from each eye using VERIS (EDI). The stimulus was a pattern-reversal dartboard. The mfVEP responses were analyzed with custom software and monocular probability plots were derived [1,2]. The mfVEP and HVF probability plots were divided into a central 10-deg. (radius) and an outer arcuate area in both hemifields. Cluster analyses and counts of abnormal points were performed in each sub-field [3,4]. Optic disc images were obtained with the Heidelberg Retina Tomograph III (HRT III) and divided into 6 segments. Segments were defined as abnormal compared to a normative database using Moorfields regression analysis.

Results: : There were no significant differences in MD and PSD values for NTG compared to HTG eyes. However, NTG eyes had a higher prevalence of cluster deficits in the central superior sub-field on both mfVEP and HVF. HTG eyes had a higher prevalence of cluster deficits in the inferior outer arcuate area for HVF. For HRT III there was no significant difference in total rim area, however the nasal segment was abnormal in significantly more HTG than NTG eyes (p<0.05) suggesting more peripheral damage in HTG in areas outside that measured by 24-2 HVF.

Conclusions: : The combined visual field and HRT data suggest more localized and central deficits for NTG as compared to more peripheral and diffuse deficits for HTG. Ref: 1. Hood et al (2002) AO. 2. Hood and Greenstein (2003) Prog Ret Eye Res. 3. Goldberg et al (2002) AJO. 4. Hood et al (2003) J Glaucoma.

Keywords: visual fields • imaging/image analysis: clinical • electrophysiology: clinical 
© 2008, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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