May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Surgical Management of Ocular Graft vs. Host Disease
Author Affiliations & Notes
  • S. K. Kim
    UT MD Anderson Cancer Center, Houston, Texas
    Ophthalmology Section,
  • J. Melton
    Ophthalmology Department, UTMB, Galveston, Texas
  • D. Couriel
    UT MD Anderson Cancer Center, Houston, Texas
    Stem Cell Transplantation,
  • R. Champlin
    UT MD Anderson Cancer Center, Houston, Texas
    Stem Cell Transplantation,
  • Footnotes
    Commercial Relationships  S.K. Kim, None; J. Melton, None; D. Couriel, None; R. Champlin, None.
  • Footnotes
    Support  Charles H. Griffenberg Memorial Fund
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 819. doi:https://doi.org/
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    • Get Citation

      S. K. Kim, J. Melton, D. Couriel, R. Champlin; Surgical Management of Ocular Graft vs. Host Disease. Invest. Ophthalmol. Vis. Sci. 2008;49(13):819. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To describe surgical intervention for the management of ocular graft. vs. host disease (GVHD).

Methods: : 30 consecutive surgical cases and the surgical techniques in acute and chronic ocular GVHD were reviewed from the Ophthalmology Section in MD Anderson Cancer Center.

Results: : 25 Cases of pseudomembranous/membranous conjunctivitis removal of symblepharon and acute membranous conjunctival tissues, 2 case of SLK removal with amniotic membrane patch graft, 3 cases of amniotic membrane graft for stage IV acute ocular GVHD were performed. Surgical techiques included in-clinic procedure, major OR procedure, and the use of Prokera amniotic membrane are described. All patients were able to undergo the procedure without complications, infections, or worsening ocular conditions.

Conclusions: : Surgical interventions in ocular GVHD patients are described. Stem cell transplantation patients with severe systemic GVHD can safely undergo ocular procedures in the acute systemic GVHD setting.

Keywords: clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials • conjunctivitis • cornea: tears/tear film/dry eye 
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