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S. K. Kim, J. Melton, D. Couriel, R. Champlin; Surgical Management of Ocular Graft vs. Host Disease. Invest. Ophthalmol. Vis. Sci. 2008;49(13):819.
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To describe surgical intervention for the management of ocular graft. vs. host disease (GVHD).
30 consecutive surgical cases and the surgical techniques in acute and chronic ocular GVHD were reviewed from the Ophthalmology Section in MD Anderson Cancer Center.
25 Cases of pseudomembranous/membranous conjunctivitis removal of symblepharon and acute membranous conjunctival tissues, 2 case of SLK removal with amniotic membrane patch graft, 3 cases of amniotic membrane graft for stage IV acute ocular GVHD were performed. Surgical techiques included in-clinic procedure, major OR procedure, and the use of Prokera amniotic membrane are described. All patients were able to undergo the procedure without complications, infections, or worsening ocular conditions.
Surgical interventions in ocular GVHD patients are described. Stem cell transplantation patients with severe systemic GVHD can safely undergo ocular procedures in the acute systemic GVHD setting.
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