May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Ocular Toxicity of Intravitreal Injections of Linezolid and Daptomycin in a Rabbit Model
Author Affiliations & Notes
  • S. Albin
    Department of Ophthalmology & Visual Sciences, University of Chicago, Chicago, Illinois
  • T. Lin
    Department of Ophthalmology & Visual Sciences, University of Chicago, Chicago, Illinois
  • L. Ulanski
    Department of Ophthalmology & Visual Sciences, University of Illinois, Chicago, Illinois
  • D. Edward
    Summa Health System, Akron, Ohio
  • D. Lee
    Department of Ophthalmology & Visual Sciences, University of Illinois, Chicago, Illinois
  • S. Langridge
    Department of Ophthalmology & Visual Sciences, University of Illinois, Chicago, Illinois
  • Footnotes
    Commercial Relationships  S. Albin, None; T. Lin, None; L. Ulanski, None; D. Edward, None; D. Lee, None; S. Langridge, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 844. doi:
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    • Get Citation

      S. Albin, T. Lin, L. Ulanski, D. Edward, D. Lee, S. Langridge; Ocular Toxicity of Intravitreal Injections of Linezolid and Daptomycin in a Rabbit Model. Invest. Ophthalmol. Vis. Sci. 2008;49(13):844.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To determine the ocular toxicity of intravitreal injections of linezolid and daptomycin in a rabbit model.

Methods: : In this study, New Zealand White Rabbits were used to evaluate toxicities of intravitreal antibiotics. Four rabbit eyes were injected with 2 mg/mL linezolid and four rabbit eyes were injected with 50 mg/mL daptomycin. Two rabbit eyes were injected with 0.1 mL of normal saline. Eye examinations were performed before injection and on days 1, 3, 7, and 14. Electroretinography was performed at day 0, before injection, and at day 14. The rabbits were euthanized on day 14, and the eyes were enucleated for light microscopy.

Results: : All eyes treated with 50 mg/mL daptomycin showed signs of ocular toxicity including conjunctival injection and cataract formation. The electroretinograms of these eyes were also extinguished. Histologic examination demonstrated extensive signs of retinal toxicity. One eye in the 2 mg/mL linezolid group developed a sectoral cataract. Electroretinograms and histologic examinations were otherwise normal as compared with the saline group.

Conclusions: : Based on the data, linezolid appears to be nontoxic at the commercially available dose of 2 mg/mL, while daptomycin appears to have considerable ocular toxicity at the commercially available dose of 50 mg/mL. Further testing is necessary at lower doses to assess for both retinal and ocular toxicity for daptomycin.

Keywords: drug toxicity/drug effects • endophthalmitis 
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