May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Neuroprotective Roles of Lutein in Endotoxin-Induced Uveitis
Author Affiliations & Notes
  • M. Sasaki
    Keio University School of Medicine, Tokyo, Japan
    Laboratory of Retinal Cell Biology,Department of Ophthalmology,
  • Y. Ozawa
    Keio University School of Medicine, Tokyo, Japan
    Laboratory of Retinal Cell Biology,Department of Ophthalmology,Department of Physiology,
  • T. Kurihara
    Laboratory of Retinal Cell Biology,Department of Ophthalmology,Department of Physiology, Keio University school of Medicine, Tokyo, Japan
  • S. Kobayashi
    Wakasa Seikatsu Co.,Ltd., Kyoto, Japan
  • K. Noda
    Keio University School of Medicine, Tokyo, Japan
    Laboratory of Retinal Cell Biology,Department of Ophthalmology,
  • Y. Imamura
    Keio University School of Medicine, Tokyo, Japan
    Laboratory of Retinal Cell Biology,Department of Ophthalmology,
  • S. Ishida
    Keio University School of Medicine, Tokyo, Japan
    Laboratory of Retinal Cell Biology,Department of Ophthalmology,
  • K. Tubota
    Keio University School of Medicine, Tokyo, Japan
    Laboratory of Retinal Cell Biology,Department of Ophthalmology,
  • Footnotes
    Commercial Relationships  M. Sasaki, None; Y. Ozawa, Wakasa seikatsu Co.,Ltd, R; T. Kurihara, None; S. Kobayashi, Wakasa seikatsu Co.,Ltd., E; K. Noda, None; Y. Imamura, None; S. Ishida, None; K. Tubota, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 865. doi:https://doi.org/
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      M. Sasaki, Y. Ozawa, T. Kurihara, S. Kobayashi, K. Noda, Y. Imamura, S. Ishida, K. Tubota; Neuroprotective Roles of Lutein in Endotoxin-Induced Uveitis. Invest. Ophthalmol. Vis. Sci. 2008;49(13):865. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To investigate the neuroprotective effects of lutein on retinal neural damage due to inflammation using a murine model of endotoxin-induced uveitis (EIU).

Methods: : EIU was induced by an intraperitoneal injection of lipopolysaccharide (LPS). Animals were subcutaneously injected with lutein or vehicle 3 times, at the same time with and 3 hours before and after LPS injection. Twenty-four hours after EIU induction, the retinal protein levels of rhodopsin were analyzed by immunoblotting. Dark-adapted full-field electroretinography (ERG) was also performed.

Results: : Compared to non-treated mice, the amplitude of a-wave was reduced together with a significant decline of rhodopsin in EIU animals. Lutein treatment led to significant suppression of these functional and molecular changes in EIU.

Conclusions: : The present data revealed the neuroprotective role of lutein in ocular inflammation, suggesting a potential validity of lutein supplementation as anti-inflammatory treatment to suppress neural damage in the retina.

Keywords: neuroprotection • inflammation • antioxidants 
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