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M. Sasaki, Y. Ozawa, T. Kurihara, S. Kobayashi, K. Noda, Y. Imamura, S. Ishida, K. Tubota; Neuroprotective Roles of Lutein in Endotoxin-Induced Uveitis. Invest. Ophthalmol. Vis. Sci. 2008;49(13):865.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the neuroprotective effects of lutein on retinal neural damage due to inflammation using a murine model of endotoxin-induced uveitis (EIU).
EIU was induced by an intraperitoneal injection of lipopolysaccharide (LPS). Animals were subcutaneously injected with lutein or vehicle 3 times, at the same time with and 3 hours before and after LPS injection. Twenty-four hours after EIU induction, the retinal protein levels of rhodopsin were analyzed by immunoblotting. Dark-adapted full-field electroretinography (ERG) was also performed.
Compared to non-treated mice, the amplitude of a-wave was reduced together with a significant decline of rhodopsin in EIU animals. Lutein treatment led to significant suppression of these functional and molecular changes in EIU.
The present data revealed the neuroprotective role of lutein in ocular inflammation, suggesting a potential validity of lutein supplementation as anti-inflammatory treatment to suppress neural damage in the retina.
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