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L. Tanga, F. Oddone, M. Centofanti, A. Tosto, V. Parisi, L. Ziccardi, B. Kroegler, R. Perricone, G. L. Manni; Functional and Morphological Retinal Changes in Patients Treated With Hydroxychloroquine. Invest. Ophthalmol. Vis. Sci. 2008;49(13):883. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the presence of early retinal impairment in patients treated with hydroxychloroquine (HXC).
Forty eight patients treated with oral HXC and 36 age mached control subjects have been included in this cross-sectional case-control study.The primary outcome measure was the difference of retinal sensitivity at Frequency Doubling Perimetry (FDT - Matrix) between cases and controls. Secondary outcome measures included differences of standard acromatic perimetry Humphrey, of multifocal erg (mfERG) and of retinal morphology. Besides a complete ophthalmological examination functional testing included FDT- Matrix 24-2 and 10-2 and Humphrey (HFA) 24-2 and 10-2 SITA- Std visual fields, and mfERG by Veris 4.9. Morphological testing included OCT and GDx imaging. T test and Mann-Whitney U test were used to analyse data.
The mean age was similar between groups (cases 51.40±11.57 yrs, controls 47.7±10.50 yrs, p=0.12).Cases showed lower mean retinal sensitivity both at FDT-Matrix 24-2 (cases 25.37±2.62 dB, controls 27.53±1.49 dB p<0.001) and at 10-2 program (cases 28.25±3.27 dB, controls 30.28±1.46 dB, p<0.0017 ). FDT - Matrix Mean Deviation was lower (-1.38±2.41 vs 0.45±1.50 dB, p<0.0001), and Pattern Standard Deviation was higher (2.70±0.65 vs 2.39±0.29 dB, p=0.0017) in cases compared to controls and this is consistent with FDT-Matrix 10-2 results.There were not statistically significant differences between the 2 groups in the Response Amplitude Density in the mfERG.None of the OCT and GDx parameters showed significant differences among groups.
The FDT Matrix can be useful in detecting early functional retinal changes induced by hydroxychloroquine.
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