May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Functional and Morphological Retinal Changes in Patients Treated With Hydroxychloroquine
Author Affiliations & Notes
  • L. Tanga
    Fondazione GB Bietti -IRCCS-, Rome, Italy
  • F. Oddone
    Fondazione GB Bietti -IRCCS-, Rome, Italy
  • M. Centofanti
    Fondazione GB Bietti -IRCCS-, Rome, Italy
    Dipartimento di Biopatologia e Diagnostica per Immagini,
    Università di Roma Tor Vergata, Rome, Italy
  • A. Tosto
    Dipartimento di Biopatologia e Diagnostica per Immagini,
    Università di Roma Tor Vergata, Rome, Italy
  • V. Parisi
    Fondazione GB Bietti -IRCCS-, Rome, Italy
  • L. Ziccardi
    Fondazione GB Bietti -IRCCS-, Rome, Italy
  • B. Kroegler
    Unità Operativa Complessa di Reumatologia,
    Università di Roma Tor Vergata, Rome, Italy
  • R. Perricone
    Unità Operativa Complessa di Reumatologia,
    Università di Roma Tor Vergata, Rome, Italy
  • G. L. Manni
    Fondazione GB Bietti -IRCCS-, Rome, Italy
    Dipartimento di Biopatologia e Diagnostica per Immagini,
    Università di Roma Tor Vergata, Rome, Italy
  • Footnotes
    Commercial Relationships  L. Tanga, None; F. Oddone, None; M. Centofanti, None; A. Tosto, None; V. Parisi, None; L. Ziccardi, None; B. Kroegler, None; R. Perricone, None; G.L. Manni, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 883. doi:
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      L. Tanga, F. Oddone, M. Centofanti, A. Tosto, V. Parisi, L. Ziccardi, B. Kroegler, R. Perricone, G. L. Manni; Functional and Morphological Retinal Changes in Patients Treated With Hydroxychloroquine. Invest. Ophthalmol. Vis. Sci. 2008;49(13):883.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To investigate the presence of early retinal impairment in patients treated with hydroxychloroquine (HXC).

Methods: : Forty eight patients treated with oral HXC and 36 age mached control subjects have been included in this cross-sectional case-control study.The primary outcome measure was the difference of retinal sensitivity at Frequency Doubling Perimetry (FDT - Matrix) between cases and controls. Secondary outcome measures included differences of standard acromatic perimetry Humphrey, of multifocal erg (mfERG) and of retinal morphology. Besides a complete ophthalmological examination functional testing included FDT- Matrix 24-2 and 10-2 and Humphrey (HFA) 24-2 and 10-2 SITA- Std visual fields, and mfERG by Veris 4.9. Morphological testing included OCT and GDx imaging. T test and Mann-Whitney U test were used to analyse data.

Results: : The mean age was similar between groups (cases 51.40±11.57 yrs, controls 47.7±10.50 yrs, p=0.12).Cases showed lower mean retinal sensitivity both at FDT-Matrix 24-2 (cases 25.37±2.62 dB, controls 27.53±1.49 dB p<0.001) and at 10-2 program (cases 28.25±3.27 dB, controls 30.28±1.46 dB, p<0.0017 ). FDT - Matrix Mean Deviation was lower (-1.38±2.41 vs 0.45±1.50 dB, p<0.0001), and Pattern Standard Deviation was higher (2.70±0.65 vs 2.39±0.29 dB, p=0.0017) in cases compared to controls and this is consistent with FDT-Matrix 10-2 results.There were not statistically significant differences between the 2 groups in the Response Amplitude Density in the mfERG.None of the OCT and GDx parameters showed significant differences among groups.

Conclusions: : The FDT Matrix can be useful in detecting early functional retinal changes induced by hydroxychloroquine.

Keywords: visual fields • drug toxicity/drug effects • retina 
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