May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Imaging the Retinopathy of Parkinson's Disease
Author Affiliations & Notes
  • M. E. Hajee
    SUNY Downstate Medical Center, Brooklyn, New York
    Ophthalmology,
    Neurology,
  • W. March
    SUNY Downstate Medical Center, Brooklyn, New York
    Ophthalmology,
  • D. Lazzaro
    SUNY Downstate Medical Center, Brooklyn, New York
    Ophthalmology,
  • Z. Belakovskaya
    Ophthalmology, Long Island College Hospital, Brooklyn, New York
  • S. Glazman
    SUNY Downstate Medical Center, Brooklyn, New York
    Neurology,
  • I. Bodis-Wollner
    SUNY Downstate Medical Center, Brooklyn, New York
    Ophthalmology,
    Neurology,
  • Footnotes
    Commercial Relationships  M.E. Hajee, None; W. March, None; D. Lazzaro, None; Z. Belakovskaya, None; S. Glazman, None; I. Bodis-Wollner, None.
  • Footnotes
    Support  NPF and NINDS
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 891. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      M. E. Hajee, W. March, D. Lazzaro, Z. Belakovskaya, S. Glazman, I. Bodis-Wollner; Imaging the Retinopathy of Parkinson's Disease. Invest. Ophthalmol. Vis. Sci. 2008;49(13):891. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : To quantify whether Parkinson’s Disease (PD), a neurodegenerative disease, affects the inner retina as measured by Fourier-Domain Optical Coherence Tomography (OCT).

Methods: : This is a prospective, multicenter study in which 46 consecutive PD eyes and 27 normal eyes were examined. Patients were in stage III or earlier phase of PD. Eighteen eyes were from non-medicated PD patients . All patients underwent a 12 point ophthalmological exam and an Optovue RTvue Fourier-Domain OCT was employed using the MM4 and MM7 scans to examine the retinal nerve fiver layer thickness (NFL). The mean ages of normal subjects and PD patients were 66.7 ± 13.5 and 66.4 ± 7.8 years (p=0.057) respectively.

Results: : The mean superior NFL of the macula in normal subjects vs. PD eyes was 99.6 vs. 86.8 (p<0.001). The mean inferior NFL of the macula in normal subjects vs. PD eyes was 97.4 vs. 85.5 (p<0.001).

Conclusions: : The NFL in PD patients is thinner than normal in a statistically significant manner. This change must be separated from glaucomatous change when using the OCT. The effect of PD on macular thinning is consistent with previous functional studies using the ERG. Retinal involvement in PD apparently is not limited to dopaminergic amacrine cells.

Keywords: retina • retina: proximal (bipolar, amacrine, and ganglion cells) • retinal connections, networks, circuitry 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×