Snapshot Retinal Oximetry: Results of A Novel Four Wavelength Oximetry Formula in Retinal Hyperspectral Imaging

Abstract

 

Purpose:

 

To introduce a novel 4 wavelength oximetry formula, and reportthe results of using this formula to study retinal oximetryusing CTIS hyperspectral imaging technology.

 

Methods:

 

The new oximetry formula is used to study oximetry in retinalvessels and the macular area in normal volunteers and patientswith retinal vascular disease.

 

Results:

 

Using this new formula, normal healthy vessels and macular backgroundare evaluated in 10 volunteers, and 20 patients with retinalvascular disease. The versatility of this 4 wavelength formulain combination with CTIS is explored in various retinal diseasesincluding diabetic retinopathy. Attached are two images fromour studies. The first example shows excellent spatial resolutionand correlation of high oxygen saturation on oxygen saturationmaps to areas of intraretinal microaneurysms and intraretinalmicrovascular abnormalities in fluorescein angiography. Thesecond image shows great ability to study the difference inoxygen saturation between arteries and veins in normal subjects.

 

Conclusions:

 

The use of hyperspectral imaging offers the potential advantageof unlimited wavelength combinations in exploring retinal oximetry.The versatility of this novel formula in combination with hyperspectralimaging adds extra flexibility in exploring retinal oximetryin health and disease.  

 

 

Keywords: imaging/image analysis: clinical • retina