May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Optical Frequency Domain Imaging of Type I Choroidal Neovascular Membranes in Age Related Macular Degeneration Patients Treated With Ranibizumab
Author Affiliations & Notes
  • D. D. Esmaili
    Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
  • D. M. de Bruin
    Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
  • D. L. Burnes
    Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
  • Y. Chen
    Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
  • S. Chang
    Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
  • T. Chen
    Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
  • J. F. de Boer
    Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
  • J. Loewenstein
    Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
  • Footnotes
    Commercial Relationships  D.D. Esmaili, None; D.M. de Bruin, None; D.L. Burnes, None; Y. Chen, None; S. Chang, None; T. Chen, None; J.F. de Boer, Patent applications on technology; royalty/licensing; sponsored research agreement Nidek Inc, Japan, P; J. Loewenstein, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 900. doi:https://doi.org/
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      D. D. Esmaili, D. M. de Bruin, D. L. Burnes, Y. Chen, S. Chang, T. Chen, J. F. de Boer, J. Loewenstein; Optical Frequency Domain Imaging of Type I Choroidal Neovascular Membranes in Age Related Macular Degeneration Patients Treated With Ranibizumab. Invest. Ophthalmol. Vis. Sci. 2008;49(13):900. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

Optical frequency domain imaging (OFDI) is a novel optical coherence tomography modality that utilizes a center wavelength of 1050 nm for improved image penetration into the choroid. This study applies OFDI to assess type I (sub-RPE) choroidal neovascularization (CNV) and its associated exudative changes in patients with age related macular degeneration (AMD) undergoing treatment with ranibizumab.

 
Methods:
 

A prototype high-speed OFDI system was used to evaluate three eyes of three patients with neovascular AMD before and after 4-8 treatments with intravitreal ranibizumab. Three-dimensional data sets encompassing a 9 by 8 by 2.5 mm (x, y, z) scanning area of the macula were acquired in 2-4 seconds, and en-face images were compiled from cross-sectional OFDI data and co-registered with color fundus photography and fluorescein angiograms (FA). The correlated cross-sectional images were analyzed and intraretinal edema, subretinal fluid, and CNV volumes were quantified during post-image processing.

 
Results:
 

OFDI revealed a band of reduced reflectivity between the RPE and Bruchs membrane in all eyes that corresponded to areas of confirmed and suspected occult CNV on FA. Following treatment, the volume of this band was reduced in all patients (mean 0.309 mm3 pre-treat, 0.165 mm3 post-treat; 46.6% reduction). Subretinal fluid (mean 0.515 mm3 pre-treat, 0.002 mm3 post-treat; 99.6% reduction) and intraretinal edema (mean 0.98 mm3 pre-treat, 0.0 mm3 post-treat) were each present in 2 eyes and essentially resolved following treatment.

 
Conclusions:
 

High speed OFDI revealed subretinal fluid, intraretinal edema, and a hyporeflective sub-RPE band presumed to be type I CNV and/or sub-RPE fluid that decreased substantially following treatment with ranibizumab. The developed OFDI system is a promising technology for imaging the retina and choroid in neovascular AMD and may be a valuable tool for assessing response to therapy.  

 
Keywords: imaging/image analysis: clinical • choroid: neovascularization • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
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