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R. Li, L. Wang, B. Li, Z. Li, R. Yang, T. Yan; The Inversion Images of Indocyanine Green Angiography in the Ultra-Late Phase for Patients With Retinal Pigment Epithelial Tears. Invest. Ophthalmol. Vis. Sci. 2008;49(13):903. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To compare the different images of Indocyanine Green Angiography (ICGA) between in the conventional observation time and in the prolonged observation time. To study the ICG dye biodistribution in the ultra-late phase through several cases with retinal pigment epithelial tears.
ICGA and Fundus Fluorescein Angiography (FFA) were performed in 4 patients affected by tears of retinal pigment epithelium. The observation time was prolonged up to 1-2 hours after dye injection, and the ultra-late phase angiograms were recorded and analyzed.
In the ultra-late phase of ICGA, inversion images that the dark visible retinal vessels appeared against the homogeneous background fluorescence were observed, which were totally different from the appearance in the conventional observation time (<30 minutes). The latter showed the background fluorescence was weaker than that of the retinal vessels. In the conventional observation time, the exposed areas of the RPE tears showed bright infrared hyperfluorescence against the weaker background fluorescence, while in the ultra-late phase, the dark visible exposed areas of the RPE tears against the homogeneous and granular background hyperfluorescence were observed.
In the conventional observation time of ICGA, a majority of the background fluorescence is the transmitted fluorescence of choroid and in the ultra-late phase, the homogeneous and granular background hyperfluorescence is caused by the ICG dye residing in the retinal pigment epithelium. The fluorescence patterns in the ultra-late phase of ICGA may help us to better diagnose and understand the diseases about RPE.
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