May 2008
Volume 49, Issue 13
ARVO Annual Meeting Abstract  |   May 2008
Morphological Differences, According to Etiology, in Pigment Epithelium Detachments Using En Face Optical Coherence Tomography
Author Affiliations & Notes
  • B. Lumbroso
    Centro Oftalmologico Mediterraneo, Rome, Italy
  • M. Savastano
    Ophthalmology, Università Cattolica del Sacro Cuore, Policlinico A. Gemelli, Rome, Italy
  • M. Rispoli
    Ophthalmology, ISTMAN Hospital, Rome, Italy
  • A. Savastano
    Seconda Università degli Studi di Napoli, Napoli, Italy
  • R. Brancato
    Ophthalmology, Instituto Scientifico San Raffaele, Milan, Italy
  • Footnotes
    Commercial Relationships  B. Lumbroso, None; M. Savastano, None; M. Rispoli, None; A. Savastano, None; R. Brancato, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 909. doi:
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      B. Lumbroso, M. Savastano, M. Rispoli, A. Savastano, R. Brancato; Morphological Differences, According to Etiology, in Pigment Epithelium Detachments Using En Face Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2008;49(13):909. doi:

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : Case study. To assess morphological differences in pigment epithelium detachments (PEDs) observed with en face optical coherence tomography in central serous retinopathy (CSC), diffuse retinal pigment epitheliopathy (DRPE) and age-related macular degeneration (AMD)

Methods: : We assessed 36 eyes of 28 consecutive patients with PED. Clinical diagnosis of recruited eyes were: 9 with CSC, 6 with DRPE and 21 affected by AMD. All patients were evaluated with en face optical coherence tomography (OCT) (Ophthalmic Technologies Inc, Toronto, Canada). Morphological PEDs aspects were estimated on C-scans and classified according to: shape, inner silhouette, contents, wall aspects, wall thickness and size.

Results: : In CSC, PED shape was predominantly circular (90%) and never showed irregular aspects; irregular and multilobular features were the mainly characteristics (77%) in AMD and, intermediate distributions between CSC and AMD was found in DRPE. PED inner silhouette had mostly smooth aspect (89%) in rare cases light granular features (11%) and did not reveal granular features in CSC; light granular (38%) and granular figures (62%) were the exclusive representations in AMD; smooth profile were absent and midway distribution between light granular and granular aspect were evident in DRPE. Clear PED contents were the most frequent representations in CSC (89%); alternatively clear (67%) and flare contents (33%) were observed in DRPE. Not univocal data were found in AMD. Morphological PED wall aspects were regular (56%) or lightly irregular (44%) in CSC and never presented irregular features. In DRPE and in AMD they were lightly irregular (67% and 52% respectively) or irregular (33% and 48% respectively). PED wall thickness and PED dimensions were always larger in AMD than in CSC and DRPE. Pearson’s correlation coefficient and Fisher’s exact in PED morphological aspects were statistically significant (p<0.01) between CSC and AMD in inner silhouette, contents and wall aspects. A relation, not statistically significant (p>0.01), was observed between DRPE and AMD. Statistically significant correlation (p<0.01) between CSC and DRPE in PED inner silhouette only was found.

Conclusions: : En face OCT was revealed useful imaging technique to detect tiny PED morphological differences in CSC, DRPE and AMD.

Keywords: retinal pigment epithelium • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • age-related macular degeneration 

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