Purchase this article with an account.
B. Lumbroso, M. Savastano, M. Rispoli, A. Savastano, R. Brancato; Morphological Differences, According to Etiology, in Pigment Epithelium Detachments Using En Face Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2008;49(13):909.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Case study. To assess morphological differences in pigment epithelium detachments (PEDs) observed with en face optical coherence tomography in central serous retinopathy (CSC), diffuse retinal pigment epitheliopathy (DRPE) and age-related macular degeneration (AMD)
We assessed 36 eyes of 28 consecutive patients with PED. Clinical diagnosis of recruited eyes were: 9 with CSC, 6 with DRPE and 21 affected by AMD. All patients were evaluated with en face optical coherence tomography (OCT) (Ophthalmic Technologies Inc, Toronto, Canada). Morphological PEDs aspects were estimated on C-scans and classified according to: shape, inner silhouette, contents, wall aspects, wall thickness and size.
In CSC, PED shape was predominantly circular (90%) and never showed irregular aspects; irregular and multilobular features were the mainly characteristics (77%) in AMD and, intermediate distributions between CSC and AMD was found in DRPE. PED inner silhouette had mostly smooth aspect (89%) in rare cases light granular features (11%) and did not reveal granular features in CSC; light granular (38%) and granular figures (62%) were the exclusive representations in AMD; smooth profile were absent and midway distribution between light granular and granular aspect were evident in DRPE. Clear PED contents were the most frequent representations in CSC (89%); alternatively clear (67%) and flare contents (33%) were observed in DRPE. Not univocal data were found in AMD. Morphological PED wall aspects were regular (56%) or lightly irregular (44%) in CSC and never presented irregular features. In DRPE and in AMD they were lightly irregular (67% and 52% respectively) or irregular (33% and 48% respectively). PED wall thickness and PED dimensions were always larger in AMD than in CSC and DRPE. Pearson’s correlation coefficient and Fisher’s exact in PED morphological aspects were statistically significant (p<0.01) between CSC and AMD in inner silhouette, contents and wall aspects. A relation, not statistically significant (p>0.01), was observed between DRPE and AMD. Statistically significant correlation (p<0.01) between CSC and DRPE in PED inner silhouette only was found.
En face OCT was revealed useful imaging technique to detect tiny PED morphological differences in CSC, DRPE and AMD.
This PDF is available to Subscribers Only