Abstract
Purpose: :
1) To compare the reproducibility of retinal thickness measurements in normal eyes using the Spectralis versus Stratus OCT2) To compare monitoring of disease progression in eyes with retinal pathology using the Spectralis versus Stratus OCT
Methods: :
Twelve normal eyes (6 subjects) underwent serial OCT examinations over five days with Stratus OCT and Spectralis. On the Stratus OCT, 6 radial scans centered on the fovea were obtained. The central retinal thickness (mean thickness in the central 1 mm diameter area) and foveal thickness (thickness measurement at the point of intersection of the 6 radial scans) were recorded. On the Spectralis, vertical and horizontal cross-sectional scans and volume scans using a raster scan pattern were obtained. Foveal thickness obtained from the cross-sectional scans and the central retinal thickness (mean thickness in the central 1 mm diameter area) were recorded. The variability of retinal thickness measurements obtained from the two systems was compared.Eyes with retinal pathology will also be examined using both OCT systems to compare the ability to monitor disease progression using the Spectralis versus Stratus OCT.
Results: :
In the normal eyes, retinal thickness measurements were less variable on the Spectralis than on Stratus OCT. On the Stratus OCT, central retinal thickness varied by a mean of 9.58 ± 4.33 µm, and foveal thickness varied by a mean of 15.17 ± 9.14 µm. On the Spectralis, central retinal thickness varied by a mean of 4.25 ± 2.68 µm, and foveal thickness varied by a mean of 6.75 ± 2.59 µm.
Conclusions: :
Compared with Stratus OCT, the Spectralis enables precise image registration and provides more reproducible measures of retinal thickness. The improved reproducibility may allow for more accurate monitoring of disease progression and/or treatment responses in patients.
Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • imaging/image analysis: clinical • image processing