May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Inter-Visit and Inter-Instrument Variability of Retinal Thickness Measurements on Healthy Subjects by CirrusTM HD-OCT
Author Affiliations & Notes
  • T. Callan
    Clinical Affairs, Carl Zeiss Meditec Inc, Dublin, California
  • M. Horne
    Clinical Affairs, Carl Zeiss Meditec Inc, Dublin, California
  • M. Durbin
    Clinical Affairs, Carl Zeiss Meditec Inc, Dublin, California
  • T. Abunto
    Clinical Affairs, Carl Zeiss Meditec Inc, Dublin, California
  • Footnotes
    Commercial Relationships  T. Callan, Carl Zeiss Meditec, Inc., E; M. Horne, Carl Zeiss Meditec, Inc., E; M. Durbin, Carl Zeiss Meditec, Inc., E; T. Abunto, Carl Zeiss Meditec, Inc., E.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 923. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      T. Callan, M. Horne, M. Durbin, T. Abunto; Inter-Visit and Inter-Instrument Variability of Retinal Thickness Measurements on Healthy Subjects by CirrusTM HD-OCT. Invest. Ophthalmol. Vis. Sci. 2008;49(13):923. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract
 
Purpose:
 

To measure the reproducibility of retinal thickness measurements from Cirrus Spectral Domain Optical Coherence Tomography (CirrusTM HD-OCT), and to determine if inter-visit or inter-instrument variability contribute significantly to overall variance.

 
Methods:
 

First, a single operator scanned one eye of fifteen (15) healthy subjects using the Cirrus HD-OCT (Carl Zeiss Meditec, Inc., Dublin, CA) Macula 200x200 scan. Subjects were imaged twice per system during a single visit on five systems. Instrument order was randomized for each subject. Then, the same operator scanned one eye of seventeen (17) healthy subjects using the Macula 200x200 scan and the Macula 512x128 scan three times per visit on three different visits. All scans for both phases were acquired within one week. Average retinal thickness measurements in nine subfields were calculated for both scan types. An analysis of variance (ANOVA) using a random effects model without interactions was performed and the calculated variance components were used to estimate the reproducibility of the measurement for each of the subfields for each scan type.

 
Results:
 

The inter-visit component was not statistically significant for any of the parameters for either scan type. The inter-instrument component was statistically significant for all parameters (P < 0.05) except the Inner Superior subfield (P = 0.056), but the component was small, contributing less than 1 µm2 to total variance in all cases. The intervisit repeatability standard deviation (SD) appeared similar for the two scan types. Reproducibility SD was calculated from the inter-system study by summing the inter-system and random variance components.  

 
Conclusions:
 

We observed minimal inter-visit variability, and only a small inter-instrument variability in this study. The small overall non-subject variance corresponds to a high degree of reproducibility for all retinal subfields measured by the Cirrus HD-OCT.

 
Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • macula/fovea • imaging/image analysis: clinical 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×