May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Quantitative Assessment of Photoreceptor Thickness in Dry Age-Related Macular Degeneration Using High Speed UHR OCT
Author Affiliations & Notes
  • L. N. Vuong
    Ophthalmology, Tufts-New England Eye Center, Boston, Massachusetts
  • V. J. Srinivasan
    Electrical Engineering and Computer Sciences, Massachusetts Institute of Technology, Boston, Massachusetts
  • I. Gorczynska
    Ophthalmology, Tufts-New England Eye Center, Boston, Massachusetts
    Electrical Engineering and Computer Sciences, Massachusetts Institute of Technology, Boston, Massachusetts
  • J. J. Liu
    Electrical Engineering and Computer Sciences, Massachusetts Institute of Technology, Boston, Massachusetts
  • J. S. Schuman
    Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • J. G. Fujimoto
    Electrical Engineering and Computer Sciences, Massachusetts Institute of Technology, Boston, Massachusetts
  • J. S. Duker
    Ophthalmology, Tufts-New England Eye Center, Boston, Massachusetts
  • Footnotes
    Commercial Relationships  L.N. Vuong, None; V.J. Srinivasan, None; I. Gorczynska, None; J.J. Liu, None; J.S. Schuman, Optovue, Inc, F; Carl Zeiss Meditec, Inc, F; Heidelberg Engineering, F; Carl Zeiss Meditec, Inc., P; Carl Zeiss Meditec, Inc., R; Heidelberg Engineering, R; J.G. Fujimoto, Optovue, Inc., F; Carl Zeiss Meditec, Inc., P; J.S. Duker, Optovue, Inc, F; Carl Zeiss Meditec, Inc, F; Topcon, Inc, F.
  • Footnotes
    Support  NIH RO1-EY11289-22, NSF BES-0522845, AFOSR FA9550-040-1-0011 and FA9550-07-1-0101, The Eye and Ear Fdn (Pittsburgh, PA), RPB unrestr. grant
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 934. doi:https://doi.org/
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      L. N. Vuong, V. J. Srinivasan, I. Gorczynska, J. J. Liu, J. S. Schuman, J. G. Fujimoto, J. S. Duker; Quantitative Assessment of Photoreceptor Thickness in Dry Age-Related Macular Degeneration Using High Speed UHR OCT. Invest. Ophthalmol. Vis. Sci. 2008;49(13):934. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To determine the correlation between photoreceptor thickness and visual acuity in patients with dry AMD using high speed, ultrahigh resolution OCT.

Methods: : Forty-one eyes from 41 patients diagnosed with dry AMD were scanned using a high speed, ultrahigh resolution OCT (UHR OCT) prototype instrument with a 3 um axial resolution at ~26,000 axial scans/second. Three high-definition images, each 6mm long and with 8192 axial scans, were acquired from the central fovea to confirm the clinical diagnosis of dry AMD. A 3-D scan protocol, which acquires 180 images of 512 axial scans each, in a 6 x 6 mm region centered on the fovea, was also performed. The five central most images were then extracted for measurement. Lines representing central foveal thickness (CFT) and foveal outer segment pigment epithelium thickness (FOSPET) were manually drawn and measured. CFT was measured from the vitreoretinal interface to the posterior surface of the RPE. In the same location, FOSPET was measured from the anterior surface of the IS/OS junction to the posterior surface of the RPE. Pearson correlations and linear regressions were calculated between: 1) CFT and logMAR 2) FOSPET and logMAR, 3) logMAR and the difference of FOSPET from CFT, and 4) CFT and FOSPET.

Results: : Patients with poor visual acuity had correspondingly disrupted or atrophied retinal pigment epithelium and thinned or compressed IS/OS layer. There was a moderate correlation between CFT and visual acuity (r = -0.442, p = 3.8x10-3) and an even stronger correlation between FOSPET and visual acuity (r = -0.605, p = 2.79x10-5). Additionally, there was strong correlation between CFT and FOSPET (r = 0.617, p = 1.73x10-5). No correlation was found between visual acuity and the difference of FOSPET from CFT (r = -0.148, p = 0.355).

Conclusions: : High speed, UHR OCT enables delineation of the photoreceptor outer segments for both qualitative and quantitative analysis of dry AMD. The FOSPET measurement may be a promising and more objective method of monitoring dry AMD to assess disease progression and guide treatment decisions.

Keywords: age-related macular degeneration • photoreceptors • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
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