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E. Anastasopoulos, A. Anastasakis, S. Kabanarou, E. Feretis, E. Tsina; Clinical, Anatomic and Electrophysiologic Evaluation Following Vitrectomy for Acute Post-Operative Endophthalmitis. Invest. Ophthalmol. Vis. Sci. 2008;49(13):965.
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To investigate clinical, anatomic, and electrophysiologic findings in patients undergone vitrectomy and silicone oil injection for acute post-operative endophthalmitis.
Seven patients (4 females/3 males) with acute post-operative endophthalmitis (six after phacoemulsification surgery and one after intravitreal injection of anti-VEGF) were treated with vitrectomy and silicone oil injection. Silicone oil was removed three months after vitrectomy. Complete eye examination was done pre- and post-operatively. Electroretinography (Full-Field Standard ERG) and Optical Coherence Tomography (OCT, fast macular thickness, macular morphology) were performed 10 days after silicone oil removal. The pre- and post-operative visual acuity measurements, intraoperative findings, and post-operative OCT and ERG recordings were analyzed.
Improvement of visual acuity (4/7 pts) was accompanied by satisfactory anatomical results, as assessed with the OCT. The presence of intraretinal hemorrhages (3/7 pts) resulted in poor visual outcome. General retinal function was compromised in all patients post-operatively as shown with the ERG testing. Rod system responses were predominantly affected.
Vitrectomy and silicone oil injection can be an effective treatment modality for preserving retinal anatomy and restoring useful central vision in Acute Post-Operative Endophthalmitis patients. However, general retinal function remains compromised. Intraretinal hemorrhages are associated with poor functional prognosis Further studies are required to assess the correlation of functional and anatomical results of the method in those patients.
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