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M. H. Amaro, C. Muccioli, M. T. Abreu; Retinal Pigment Epithelium Infiltration of Non-Hodgkin's Lymphoma. Invest. Ophthalmol. Vis. Sci. 2008;49(13):969.
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To relate the ocular clinical findings of a patients series with Large Cells non-Hodgkin's Lymphoma,including Primary Central Nervous System and Systemic form.
Sixteen eyes from eight patients with Large cells non-Hodgkin's Lymphoma ,4 patients with Central Nervous System non-Hodgkin's Lymphoma and 4 patients with Systemic non-Hodgkin's Lymphoma were evaluated between january 1992 and September 2007 All patients were submitted an ocular examination including Fluorescein Angiography, Indocyanine Green Angiography and Ultrasonography
We found two forms of Retinal Pigment Epithelium Infiltration in two patients with Ocular non-Hodgkin's Lymphoma.One patient presented gray-white flecks of the Retinal Pigment Epithelium in the posterior and equatorial fundus in one eye,the patient had Systemic form of the non-Hodgkin's Lymphoma and the other patient presented multiple yellowish-tan ,variable-sized and - shaped detachments of the Retinal Pigment Epithelium widely scattered throughout in the posterior pole and the macula region in one eye, the patient had Central Nervous System non-Hodgkin's Lymphoma.
Unusual forms of the ocular fundus involvement of the Large Cells non-Hodgkin's Lymphoma were described. For Gass who described the both forms there is some overlap in the two forms of Large Cells non-Hodgkin's Lymphoma.Researchers from the National Eye Institute in the United States published different patterns of the FA confirmed by histopathologic analysis, the most commum pattern were disturbances of the RPE level,they were granularity,blockage and late staining ,neither characteristics found in our cases.
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