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S. Hirahara, M. Nozaki, A. Ito, A. Takase, Y. Hirano, A. Matsubara, M. Yoshida, Y. Ogura; Selective Laser Trabeculoplasty for Intraocular Pressure Elevation After Triamcinolone Acetonide Injection. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1238.
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Triamcinolone acetonide (TA) injection has increasingly become a therapeutic option for neovascular, inflammatory, and edematous intraocular diseases. The purpose of this study was to evaluate the efficacy of selective laser trabeculoplasty (SLT) for intraocular pressure (IOP) elevation after local administration of TA.
Retrospective, interventional case series design was used. SLT was performed on 7 cases (7 eyes) with IOP elevation after TA injection. Median follow-up was 33 months (range, 13 to 40 months). The mean age of patients was 44 (range 22-64) years. TA was administered because of diabetic macular edema (2 eyes), macular edema after branch retinal vein occlusion (2 eyes) and choroidal neovascularization in pathological myopia (3 eyes). TA was applied by sub-Tenon injection in 3 eyes and simultaneous sub-Tenon and intravitreal injections in 4 eyes.
SLT effectively decreased IOP from 28 - 46 mmHg (mean 34.3 mmHg) to 9 -16 mmHg (mean 14.2 mmHg) (p<0.01). Overall success rate (IOP <20 mm Hg with or without medications and no subsequent surgery) was 86% (6 eyes). The mean time for IOP to stabilize was 31 days (range 7-42 days) after SLT. Although the IOP was well controlled with SLT, one eye with pathological myopia subsequently underwent trabeculotomy because of the progression of visual field defect.
Our data suggested that SLT is useful to treat IOP elevation after local administration of TA.
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