Purchase this article with an account.
M. M. Gajecka, M. Rydzanicz, M. Podfigurna-Musielak, M. Mrugacz, A. Frajdenberg, K. Lee, S. M. Leal, K. Pecold, B. A. Bejjani; High Myopia in Polish Families. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1295. doi: https://doi.org/.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Myopia is the most common of all ocular conditions. In high myopia, genetic factors appear to play a predominant role. The purpose of this study is to map a gene(s) responsible for high myopia in a Polish population.
To date, we have examined, collected blood and purified DNA from 335 individuals with high myopia (<-6 diopters) from 62 unrelated families in Poland. Prior to the targeting genotyping, linkage to markers for the myopic genetic syndromes were tested and genotyping of high myopia associated loci was performed. Next, we performed genome wide screen with fluorescent markers with an average spacing of 8 cM spanning all chromosomes.
Previously assigned high myopia loci were excluded in Polish families. The genome-wide screen for a high myopia identified three novel loci. These loci are currently being verified using SNP array in the largest multigenerational family.
We have identified, collected and characterized a large cohort of polish families with high myopia and excluded the principal genetic cause of this phenotype. These families will be instrumental in identifying one or more locus for genetic high myopia.
This PDF is available to Subscribers Only