May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
High Myopia in Polish Families
Author Affiliations & Notes
  • M. M. Gajecka
    Washington State University, Spokane, Washington
    Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland
  • M. Rydzanicz
    Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland
  • M. Podfigurna-Musielak
    Department of Ophthalmology, Hospital, Leszno, Poland
  • M. Mrugacz
    Department of Pediatric Opthalmology, Medical University of Bialystok, Bialystok, Poland
  • A. Frajdenberg
    Department of Ophthalmology, Marcinkowski University of Medical Sciences, Poznan, Poland
  • K. Lee
    Baylor College of Medicine, Houston, Texas
  • S. M. Leal
    Baylor College of Medicine, Houston, Texas
  • K. Pecold
    Department of Ophthalmology, Marcinkowski University of Medical Sciences, Poznan, Poland
  • B. A. Bejjani
    Washington State University, Spokane, Washington
    Sacred Heart Medical Center, Spokane, Washington
  • Footnotes
    Commercial Relationships  M.M. Gajecka, None; M. Rydzanicz, None; M. Podfigurna-Musielak, None; M. Mrugacz, None; A. Frajdenberg, None; K. Lee, None; S.M. Leal, None; K. Pecold, None; B.A. Bejjani, None.
  • Footnotes
    Support  Ministry of Education and Science, Poland, P05 Grant (2 P05A 095 29)
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1295. doi:https://doi.org/
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      M. M. Gajecka, M. Rydzanicz, M. Podfigurna-Musielak, M. Mrugacz, A. Frajdenberg, K. Lee, S. M. Leal, K. Pecold, B. A. Bejjani; High Myopia in Polish Families. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1295. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Myopia is the most common of all ocular conditions. In high myopia, genetic factors appear to play a predominant role. The purpose of this study is to map a gene(s) responsible for high myopia in a Polish population.

Methods: : To date, we have examined, collected blood and purified DNA from 335 individuals with high myopia (<-6 diopters) from 62 unrelated families in Poland. Prior to the targeting genotyping, linkage to markers for the myopic genetic syndromes were tested and genotyping of high myopia associated loci was performed. Next, we performed genome wide screen with fluorescent markers with an average spacing of 8 cM spanning all chromosomes.

Results: : Previously assigned high myopia loci were excluded in Polish families. The genome-wide screen for a high myopia identified three novel loci. These loci are currently being verified using SNP array in the largest multigenerational family.

Conclusions: : We have identified, collected and characterized a large cohort of polish families with high myopia and excluded the principal genetic cause of this phenotype. These families will be instrumental in identifying one or more locus for genetic high myopia.

Keywords: myopia • gene mapping 
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