May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Genotype/Phenotype Correlation of Htra1 Polymorphism and Serum MMP/TIMP Profile in Neovascular AMD
Author Affiliations & Notes
  • T. Adewoyin
    Ophthalmology, King's College Hospital, London, United Kingdom
    Clinical Ophthalmology, Institute of Ophthalmology, London, United Kingdom
  • E. Fletcher
    Ophthalmology, King's College Hospital, London, United Kingdom
    Clinical Ophthalmology, Institute of Ophthalmology, London, United Kingdom
  • V. Chong
    Ophthalmology, King's College Hospital, London, United Kingdom
  • Footnotes
    Commercial Relationships  T. Adewoyin, None; E. Fletcher, None; V. Chong, None.
  • Footnotes
    Support  King's Research Fund, Macular Disease Society
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1362. doi:https://doi.org/
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      T. Adewoyin, E. Fletcher, V. Chong; Genotype/Phenotype Correlation of Htra1 Polymorphism and Serum MMP/TIMP Profile in Neovascular AMD. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1362. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To ascertain if the serum MMP/TIMP profile in patients with neovascular AMD differs compared to controls and with regard their allelic variation of HTRA1

Methods: : A pilot cohort of 60 Caucasian patients from a sample of 240 patients, classified into controls, early AMD (drusen) and neovascular AMD were genotyped for HTRA1 (rs11200638). The serum MMP/TIMP profile was examined using human MMP/TIMP protein microarray, to determine quantitatively the amount of 14 different MMPs/TIMPs

Results: : The serum MMP-2 was decreased and MMP-9 was elevated in AMD compared to normal controls. The serum level of MMP-3, 8 and 9 showed a trend of association with homozygotes of the HTRA1 "at risk" allele

Conclusions: : HTRA1 has been shown to confer an increased risk of AMD possibly through the regulation of extracellular matrix proteins in Bruch’s membrane. Our study supported this hypothesis but further data is required to confirm the association

Keywords: age-related macular degeneration • Bruch's membrane • macula/fovea 
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