May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Analysis of Cytokine Profiles in Patients With Different Stage of Age-Related Macular Degeneration
Author Affiliations & Notes
  • F. Mo
    Schepens Eye Research Institute, Boston, Massachusetts
  • K. Lashkari
    Schepens Eye Research Institute, Boston, Massachusetts
  • Footnotes
    Commercial Relationships  F. Mo, None; K. Lashkari, Novartis Institutes for Biomedical Research, F.
  • Footnotes
    Support  Supported by an unrestricted grant from Novartis Institutes for Biomedical Research
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1364. doi:
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      F. Mo, K. Lashkari; Analysis of Cytokine Profiles in Patients With Different Stage of Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1364.

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Abstract

Purpose: : Inflammation may significantly participate in the pathogenesis of age-related macular degeneration (AMD). The contribution of humoral factors such as cytokines and chemokines in relation to pathogenesis of AMD is not well understood. We have analyzed cytokines from sera of patients with various stages of AMD, and have compared them with those from patients with no phenotype or family history of AMD.

Methods: : AMD patients with the following 4 phenotypes (n= 20/group) were recruited into the study: AREDS stage I, AREDS stage III, geographic atrophy and choroidal neovascularization. Patients were examined by slit lamp biomicroscopy, optical coherence tomography, fundus photography and fluorescein angiography when indicated. on their retina and blood samples were withdraw. The control group was selected from age-matched patients with clinical evidence and no family history of AMMD. Plasma and serum samples were collected and processed using a multi-cytokine Bio-plex system.

Results: : Eight of twenty-seven cytokines were significantly increased in sera of AMD patients compared with the control group. These included certain (1) pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and platelet derived growth factor bb (PDGF-bb), and (2). pro-inflammatory factors such as, gamma-interferon (IFN-g), macrophage inflammatory protein 1 α (MIP-1α) and MIP-1β. We also profiled the change of plasma cytokines in relation to different stages of AMD.

Conclusions: : Our results suggest some certain plasma pro-angiogenic and pro-inflammatory cytokines are significantly altered in AMD patients. These cytokines may play a role in progression to more advanced stage of AMD such as geographic atrophy or neovascular AMD is being investigated.

Keywords: age-related macular degeneration • cytokines/chemokines • clinical (human) or epidemiologic studies: risk factor assessment 
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