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F. Mo, K. Lashkari; Analysis of Cytokine Profiles in Patients With Different Stage of Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1364.
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Inflammation may significantly participate in the pathogenesis of age-related macular degeneration (AMD). The contribution of humoral factors such as cytokines and chemokines in relation to pathogenesis of AMD is not well understood. We have analyzed cytokines from sera of patients with various stages of AMD, and have compared them with those from patients with no phenotype or family history of AMD.
AMD patients with the following 4 phenotypes (n= 20/group) were recruited into the study: AREDS stage I, AREDS stage III, geographic atrophy and choroidal neovascularization. Patients were examined by slit lamp biomicroscopy, optical coherence tomography, fundus photography and fluorescein angiography when indicated. on their retina and blood samples were withdraw. The control group was selected from age-matched patients with clinical evidence and no family history of AMMD. Plasma and serum samples were collected and processed using a multi-cytokine Bio-plex system.
Eight of twenty-seven cytokines were significantly increased in sera of AMD patients compared with the control group. These included certain (1) pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and platelet derived growth factor bb (PDGF-bb), and (2). pro-inflammatory factors such as, gamma-interferon (IFN-g), macrophage inflammatory protein 1 α (MIP-1α) and MIP-1β. We also profiled the change of plasma cytokines in relation to different stages of AMD.
Our results suggest some certain plasma pro-angiogenic and pro-inflammatory cytokines are significantly altered in AMD patients. These cytokines may play a role in progression to more advanced stage of AMD such as geographic atrophy or neovascular AMD is being investigated.
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