May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Oxidative Stress Markers in Japanese Patients With Age-Related Macular Degeneration: A Pilot Study
K. Hashizume; Y. Imamura; M. Hirasawa; M. Sawanobori; S. Ishida; D. Kurosaka; K. Tsubota
Author Affiliations & Notes
  • K. Hashizume
    Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Iwate Medical University, Morioka, Japan
  • Y. Imamura
    Ophthalmology, Inaida Laboratory of Anti-aging, Tokyo, Japan
    Laboratory of Retinal Cell Biology, Tokyo, Japan
  • M. Hirasawa
    Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Laboratory of Retinal Cell Biology, Tokyo, Japan
  • M. Sawanobori
    GOKIGEN Clinic, Tokyo, Japan
  • S. Ishida
    Ophthalmology, Inaida Laboratory of Anti-aging, Tokyo, Japan
    Laboratory of Retinal Cell Biology, Tokyo, Japan
  • D. Kurosaka
    Ophthalmology,
    Iwate Medical University, Morioka, Japan
  • K. Tsubota
    Ophthalmology, Keio University School of Medicine, Tokyo, Japan
  • Footnotes
    Commercial Relationships  K. Hashizume, None; Y. Imamura, None; M. Hirasawa, None; M. Sawanobori, None; S. Ishida, None; D. Kurosaka, None; K. Tsubota, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1368. doi:
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      K. Hashizume, Y. Imamura, M. Hirasawa, M. Sawanobori, S. Ishida, D. Kurosaka, K. Tsubota; Oxidative Stress Markers in Japanese Patients With Age-Related Macular Degeneration: A Pilot Study. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1368.

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Abstract

Purpose: : To identify biomarkers related with oxidative stress in patients with age-related macular degeneration (AMD).

Methods: : We screened serum and urinay levels of various markers which show the oxidative damage. We selected 50 patients with geographic atrophy or choroidal neovascularization and 50 subjects without any retinal vascular diseases. Screened markers were as follows: urinary levels of 8-hydro-2`deoxyguanosine and 15-isoprastane F2t, and serum levels of oxidized form of coenzyme Q10, lipid peroxide (LPO), iron, ferittin, copper, and ubiquinol. Total antioxidant status (TAS) was also measured.

Results: : In AMD group, serum levels of oxidized coenzyme Q10 and LPO were significantly elevated, while TAS was decreased.

Conclusions: : Although this study is preliminary, oxidized coenzyme Q10 and LPO may be biomarkers of AMD. These findings suggest AMD may be associated with increased oxidative stress due to a poor antioxidant status.

Keywords: age-related macular degeneration • oxidation/oxidative or free radical damage • antioxidants 
© 2008, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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