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K. Hashizume, Y. Imamura, M. Hirasawa, M. Sawanobori, S. Ishida, D. Kurosaka, K. Tsubota; Oxidative Stress Markers in Japanese Patients With Age-Related Macular Degeneration: A Pilot Study. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1368.
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To identify biomarkers related with oxidative stress in patients with age-related macular degeneration (AMD).
We screened serum and urinay levels of various markers which show the oxidative damage. We selected 50 patients with geographic atrophy or choroidal neovascularization and 50 subjects without any retinal vascular diseases. Screened markers were as follows: urinary levels of 8-hydro-2`deoxyguanosine and 15-isoprastane F2t, and serum levels of oxidized form of coenzyme Q10, lipid peroxide (LPO), iron, ferittin, copper, and ubiquinol. Total antioxidant status (TAS) was also measured.
In AMD group, serum levels of oxidized coenzyme Q10 and LPO were significantly elevated, while TAS was decreased.
Although this study is preliminary, oxidized coenzyme Q10 and LPO may be biomarkers of AMD. These findings suggest AMD may be associated with increased oxidative stress due to a poor antioxidant status.
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