May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Effect of Topical -Tocopherol on Galactose Induced Cataract in Guinea Pigs
Author Affiliations & Notes
  • A. Azimi Khorasani
    Mashad Medical Sciences University, Mashad, Iran, Islamic Republic of
    Optometry,
  • M. Salehi Fadardi
    Mashad Medical Sciences University, Mashad, Iran, Islamic Republic of
    Optometry,
  • M. Tafaghodi
    Mashad Medical Sciences University, Mashad, Iran, Islamic Republic of
    Pharmacology,
  • Footnotes
    Commercial Relationships  A. Azimi Khorasani, None; M. Salehi Fadardi, None; M. Tafaghodi, None.
  • Footnotes
    Support  Partially by Mashad medical sciences univerity
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1466. doi:https://doi.org/
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    • Get Citation

      A. Azimi Khorasani, M. Salehi Fadardi, M. Tafaghodi; Effect of Topical -Tocopherol on Galactose Induced Cataract in Guinea Pigs. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1466. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Vitamin E is the major lipid -soluble chain-breaking antioxidant. It has been shown that supplement of vitamin E has attenuated the pathologic outcomes associated with imposed oxidant stress by various agents. The aim of this study was to investigate the effect of vitamin E on the onset and maturation of galactose induced cataract.

Methods: : 20 pigmented guinea pigs divided into four groups: 1) with normal guinea pig diet chow. 2) With 50% galactose diet chow 3) with 50% galactose diet chow applied α-tocopherol drop (97%, 10 µlit per administration per eye) in the cul-de-sac a day. 4) with 50% galactose diet chow received non antioxidant oil drop administrated 10µlit per eye in the cul-de-sac a day .During 22 follow up days, the progress of cataract was monitored by slit lamp and clinical observations classified in 5 grades of cataract.

Results: : Clinical observations in first 3 days show significant reduction of cataract formation for the group with vitamin E administration. 10 days treatment with topical α-tocopherol drop led to decrease of cataract grades which was significant in group 3 compared to group 4. Clinical examinations in 22 follow up days showed that the risk of cataract formation was low for group with α-tocopherol eye drop.

Conclusions: : Supplemented eye drops with vitamin E antioxidant following galactose diet exposure can be effective to slow down cataract formation. It can reduce the initial observations of progression of galactose induced cataract and may be effective to oxidant defense of lens.

Clinical Trial: : Mashad medical sciences university of Iran

Keywords: cataract • antioxidants • drug toxicity/drug effects 
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