May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Suramab, a Pharmaceutical Compound of Bevacizumab and Suramin, Strongly Inhibits Vessels Growth in a Rabbit Model of Corneal Neovascularization
Author Affiliations & Notes
  • E. S. Lopez
    Universidad Austral, Pilar, Argentina
    Research Area,
  • J. Croxatto
    Ocular Pathology, Fundación Oftalmológica Argentina, Buenos Aires, Argentina
  • A. Kvanta
    St Erik Eye Hospital, Karolinska Institute, Stockholm, Sweden
  • J. Gallo
    Universidad Austral, Pilar, Argentina
    Department of Ophthalmology,
  • Footnotes
    Commercial Relationships  E.S. Lopez, None; J. Croxatto, None; A. Kvanta, None; J. Gallo, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1491. doi:
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      E. S. Lopez, J. Croxatto, A. Kvanta, J. Gallo; Suramab, a Pharmaceutical Compound of Bevacizumab and Suramin, Strongly Inhibits Vessels Growth in a Rabbit Model of Corneal Neovascularization. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1491.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : In previous studies we showed that intravenous Suramin (20 mg/kg) and Bevacizumab (5 mg/kg), separately, diminished corneal neovascularization. The present study aims to evaluate a possible synergistic effect of the two drugs.

Methods: : Corneal NV was induced in two groups of nine White New Zealand rabbits, applying a filter paper disc soaked in 1M Na (OH) on the central cornea. Group one was treated after injury with intravenous Suramab at a doses equivalent to 3mg./kg of bevacizumab and 10mg./kg of suramin. The control group received no treatment. Digital photographs were taken at days 9, 15, 21 and 35. NV index (NVI) was calculated using the jimage program. Neovessels formation was quantified given a score from 0 to 4 to each quadrant according to the centripetal growth of the longest vessel. Scores of the four quadrants were summed to obtain the NVI.

Results: : Nine days after injury, the NVI was much higher in the control group (mean 4.7) than in the treated group (mean 1.5). Suramab significantly reduced neovessels formation (mean 6.1) compared with control animals (mean 13) at 35 days(p<0,01).

Conclusions: : The systemic application of Suramab reduced corneal neovascularization. Duration of the effect was longer than that previously obtained with higher monodoses of Bevacizumab and Suramin. Results suggest the presence of pharmacological synergia.

Keywords: cornea: clinical science • neovascularization • vascular endothelial growth factor 
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