May 2008
Volume 49, Issue 13
ARVO Annual Meeting Abstract  |   May 2008
Compliance: An Objective Evaluation in Glaucoma Patients of Eye-Drop Instillation Using Video Observations and Patient Surveys
Author Affiliations & Notes
  • J. L. Stone
    Alan L. Robin M.D., PA, Baltimore, Maryland
  • A. L. Robin
    Alan L. Robin M.D., PA, Baltimore, Maryland
    Johns Hopkins University, Baltimore, Maryland
  • B. Sleath
    School of Pharmacy, University North Carolina, Chapel Hill, North Carolina
  • D. W. Covert
    Alcon, Fort Worth, Texas
  • G. Cagle
    Alcon, Fort Worth, Texas
  • G. D. Novack
    PharmaLogic Development Inc., San Rafael, California
  • Footnotes
    Commercial Relationships  J.L. Stone, None; A.L. Robin, Alcon, I; Alcon, Ista, Merck, Pfizer, Glaucos, C; Alcon, P; B. Sleath, Alcon, C; D.W. Covert, Alcon, E; G. Cagle, Alcon, E; G.D. Novack, Alcon, C.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1580. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      J. L. Stone, A. L. Robin, B. Sleath, D. W. Covert, G. Cagle, G. D. Novack; Compliance: An Objective Evaluation in Glaucoma Patients of Eye-Drop Instillation Using Video Observations and Patient Surveys. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1580. doi:

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Purpose: : Patient compliance with glaucoma medications requires not only remembering to take an eye drop, but also placing the drop on the eye. This study investigates both patients’ perceptions of their eye drop instillation and actual eye-drop delivery.

Methods: : We evaluated 140 consecutive glaucoma patients, who first completed a brief questionnaire regarding their drop delivery. We video-recorded patients instilling artificial tears from either low density polyethylene bottles, Boston round bottles, or both.

Results: : Subjects ranged in age from 21-94 yrs. (mean 67.5 +/-13.5 yrs.), 55% were female and 69% Caucasian. 95% (134/140) had been treated more than one year. Subjects perceived a high level of success with self-instillation according to their survey responses. 93% (130/140) reported no trouble instilling drops, and 51% (72/140) reported never missing their eye during delivery. Our review of the videos revealed only 83% (116/140) of patients accurately administered to the eye, 51% (72/140) were able to use the bottle without contamination, and 44% (62/140) were able to squeeze 1 drop from the bottle. Only 29% (40/140) of subjects achieved successful instillations, which were required to meet all three criteria. 39% (55/140) of subjects reported receiving prior instruction on appropriate instillation technique.

Conclusions: : In this study population, objective patient performance during self-instillation of eye drops was much worse than perceived by patients. Assuming our in-office observations are no worse than in-home instillation by patients, we interpret low performance success of only 29%. We recommend eye care providers evaluate patient self-instillation performance. Further studies are required to evaluate the role of patient education in their performance.

Clinical Trial: : nct00522600

Keywords: quality of life • clinical (human) or epidemiologic studies: health care delivery/economics/manpower • clinical (human) or epidemiologic studies: systems/equipment/techniques 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.