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D. H. Su, N. Amerasinghe, T. Aung, N. Cheung, C. W. Fong, J. J. Wang, P. Mitchell, S. M. Saw, T. Y. Wong; The Relationship of Retinal Vascular Caliber and Glaucoma: The Singapore Malay Eye Study. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1594.
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To examine the relationship between retinal vascular caliber and glaucoma in an elderly Asian population.
This was a population based, cross-sectional study of 3,019 Asian Malays adults aged 40-80 years residing in Singapore. All participants had retinal photographs taken of both eyes after papillary dilation. Retinal vascular caliber was measured using a computer-based technique following a standardized protocol. Glaucoma was diagnosed based on the International Society of Geographic and Epidemiological Ophthalmology (ISGEO) classification and included people with glaucomatous optic neuropathy and compatible visual field loss.
There were 127 (4.2%) participants with glaucoma. The mean retinal arteriolar calibers were narrower in people with (136.4µm) than those without (139.7µm) glaucoma (p=0.02). A similar relationship was seen for retinal venular caliber (209.2µm vs 219.7µm, p<0.001). After adjusting for age, gender, smoking, and other vascular risk factors, both narrower retinal arteriolar and venular caliber were associated with increased odds of glaucoma (odds ratio [OR] 1.30; 95% confidence interval [CI]: 1.06, 1.59 and OR 1.61; 95% CI: 1.33, 1.96, comparing a standard deviation decrease in arteriolar and venular caliber, respectively). A vertical cup to disc ratio ≥ 0.5 was also associated with narrower retinal arteriolar and venular caliber (OR 1.18; 95% CI: 1.07, 1.30 and OR 1.29; 95% CI: 1.18, 1.42, respectively). Retinal arteriolar or venular calibers were not associated with intraocular pressure.
Persons with glaucoma are more likely to have narrower retinal vessels. These findings support the association of retinal microvascular changes with the glaucomatous optic neuropathy.
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