May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
The Relationship of Retinal Vascular Caliber and Glaucoma: The Singapore Malay Eye Study
Author Affiliations & Notes
  • D. H. Su
    Singapore National Eye Centre, Singapore, Singapore
  • N. Amerasinghe
    Singapore National Eye Centre, Singapore, Singapore
  • T. Aung
    Singapore National Eye Centre, Singapore, Singapore
    Singapore Eye Research Institute, Singapore, Singapore
  • N. Cheung
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
  • C. W. Fong
    Epidemiology & Disease Control Division, Ministry of Health, Singapore, Singapore
  • J. J. Wang
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
    Centre for Vision Research, University of Sydney, Sydney, Australia
  • P. Mitchell
    Centre for Vision Research, University of Sydney, Sydney, Australia
  • S. M. Saw
    Singapore Eye Research Institute, Singapore, Singapore
    Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
  • T. Y. Wong
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
    Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
  • Footnotes
    Commercial Relationships  D.H. Su, None; N. Amerasinghe, None; T. Aung, None; N. Cheung, None; C.W. Fong, None; J.J. Wang, None; P. Mitchell, None; S.M. Saw, None; T.Y. Wong, None.
  • Footnotes
    Support  National Medical Research Council Grants No. 0796/2003, 0863/2004, CSI/0002/2005 ,and Biomedical Research Council Grant No. 501/1/25-5
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1594. doi:https://doi.org/
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      D. H. Su, N. Amerasinghe, T. Aung, N. Cheung, C. W. Fong, J. J. Wang, P. Mitchell, S. M. Saw, T. Y. Wong; The Relationship of Retinal Vascular Caliber and Glaucoma: The Singapore Malay Eye Study. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1594. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To examine the relationship between retinal vascular caliber and glaucoma in an elderly Asian population.

Methods: : This was a population based, cross-sectional study of 3,019 Asian Malays adults aged 40-80 years residing in Singapore. All participants had retinal photographs taken of both eyes after papillary dilation. Retinal vascular caliber was measured using a computer-based technique following a standardized protocol. Glaucoma was diagnosed based on the International Society of Geographic and Epidemiological Ophthalmology (ISGEO) classification and included people with glaucomatous optic neuropathy and compatible visual field loss.

Results: : There were 127 (4.2%) participants with glaucoma. The mean retinal arteriolar calibers were narrower in people with (136.4µm) than those without (139.7µm) glaucoma (p=0.02). A similar relationship was seen for retinal venular caliber (209.2µm vs 219.7µm, p<0.001). After adjusting for age, gender, smoking, and other vascular risk factors, both narrower retinal arteriolar and venular caliber were associated with increased odds of glaucoma (odds ratio [OR] 1.30; 95% confidence interval [CI]: 1.06, 1.59 and OR 1.61; 95% CI: 1.33, 1.96, comparing a standard deviation decrease in arteriolar and venular caliber, respectively). A vertical cup to disc ratio ≥ 0.5 was also associated with narrower retinal arteriolar and venular caliber (OR 1.18; 95% CI: 1.07, 1.30 and OR 1.29; 95% CI: 1.18, 1.42, respectively). Retinal arteriolar or venular calibers were not associated with intraocular pressure.

Conclusions: : Persons with glaucoma are more likely to have narrower retinal vessels. These findings support the association of retinal microvascular changes with the glaucomatous optic neuropathy.

Keywords: clinical (human) or epidemiologic studies: risk factor assessment 
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