May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Intraocular Pressure Profile of Children With Acute Lymphoblastic Leukemia on a Systemic Corticosteroid
Author Affiliations & Notes
  • T. Yamashita
    Kagoshima Univ, Kagoshima-Shi, Japan
    Dept of Ophthal,
  • Y. Kodama
    Kagoshima Univ, Kagoshima-Shi, Japan
    Dept of Pediatrics,
  • Y. Kawano
    Kagoshima Univ, Kagoshima-Shi, Japan
    Dept of Pediatrics,
  • T. Sakamoto
    Kagoshima Univ, Kagoshima-Shi, Japan
    Dept of Ophthal,
  • Footnotes
    Commercial Relationships  T. Yamashita, None; Y. Kodama, None; Y. Kawano, None; T. Sakamoto, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1596. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      T. Yamashita, Y. Kodama, Y. Kawano, T. Sakamoto; Intraocular Pressure Profile of Children With Acute Lymphoblastic Leukemia on a Systemic Corticosteroid. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1596. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : To evaluate the ocular hypertensive response to repetitive cycles of high-dose systemic corticosteroid in young patients with acute lymphoblastic leukemia (ALL).

Methods: : Five patients up to 6 years of age with ALL who received chemotherapy between November 2003 and March 2005 were examined. They received oral or intravenous prednisolone (60 mg/m2/day) for 4 weeks during remission induction therapy and then dexamethasone (12 mg/m2/day) for 2 weeks, followed by 1-week tapering and 5-week break during maintenance phase (15 cycles). Comprehensive ophthalmic check-up, including best-corrected visual acuity, intraocular pressure (IOP), and slit-lamp and fundus examinations, were performed.

Results: : All patients were followed up until final cycle. IOP >21 mmHg was observed in all patients. IOP increased to a maximum of mean 40.6±9.0 (range 28-53) mmHg. The range of cycle to reach a maximal IOP was 2 to 11. All patients were maintained IOP control with antiglaucoma medications. However, one patient had severe glaucomatous optic atrophy.

Conclusions: : Systemic corticosteroid in childhood-ALL treatment frequently causes severe IOP rise. Periodical and careful ophthalmic check-up is necessary.

Keywords: corticosteroids • drug toxicity/drug effects • intraocular pressure 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×