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M. Schargus, G. Gramer, E. Gramer; Central Corneal Thickness in Patients With Ocular Hypertension and Primary Open Angle Glaucoma Correlated With Glaucoma Damage. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1597.
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To evaluate: 1. whether there are differences in the CCT between patients with POAG and Ocular Hypertension (OH) 2. whether there is a significant relationship between CCT and the presence and stage of VFL. 3. the change in the frequency distribution of maximum IOP (IOP max) after correction of Goldmann applanation tonometry (GAT) readings by considering the CCT.
CCT was measured in 115 consecutive patients with POAG and 73 patients with OH (IOP >21 mmHg) using ultrasonic pachymetry (Tomey AL-2000). For this study the right eye was included in the evaluation. A correction of IOP readings by considering CCT according to the Dresdner correction table was performed. Automated perimetry (Octopus; program Gd2) and Goldmann perimetry was performed. Stage of VFL was defined according to the Aulhorn classification. IOP readings were obtained by GAT and the maximum IOP, defined as highest IOP ever measured with or without medication was used for evaluation.Pearsons test was performed to determine the correlation of CCT and severity of VFL and ANOVA test to compare CCT between groups.
1. There was a significant difference in the mean CCT between OH (573µm (+/- 37,6µm)) and POAG (539µm (+/- 36,1µm) (p<0,05; ANOVA test)2. There was no significant relationship between the stage of VFL and CCT (p=0,88; Pearsons test)3. Frequency distribution of the IOP max readings in POAG without vs with CCT adjusted correction showed that in 2% of the patients the CCT adjusted IOP changed the diagnosis to Normal Tension Glaucoma (NTG) (IOP max ≤21 mmHg).
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