May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Does the Endothelium of the Schlemm Canal Belong to Lymphatic or Blood Vessels From the Aspect of the Platelet Coagulation System?
Author Affiliations & Notes
  • Y. Yajima
    Ophthalmology, Juntendo Univ School of Medicine, Tokyo, Japan
    Ophthalmology,
    Japan Red Cross Medical Center, Tokyo, Japan
  • T. Hamanaka
    Ophthalmology,
    Japan Red Cross Medical Center, Tokyo, Japan
  • T. Takemura
    Pathology,
    Japan Red Cross Medical Center, Tokyo, Japan
  • A. Murakami
    Ophthalmology, Juntendo Univ School of Medicine, Tokyo, Japan
  • T. Omata
    Ophthalmology,
    Japan Red Cross Medical Center, Tokyo, Japan
  • S. Sekimoto
    Ophthalmology,
    Japan Red Cross Medical Center, Tokyo, Japan
  • Footnotes
    Commercial Relationships  Y. Yajima, None; T. Hamanaka, None; T. Takemura, None; A. Murakami, None; T. Omata, None; S. Sekimoto, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1621. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Y. Yajima, T. Hamanaka, T. Takemura, A. Murakami, T. Omata, S. Sekimoto; Does the Endothelium of the Schlemm Canal Belong to Lymphatic or Blood Vessels From the Aspect of the Platelet Coagulation System?. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1621. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract
 
Purpose:
 

The Schlemm canal functions as a lymphatic vessel, because aqueous fluid passes from outside to inside of the canal. It has been proved that the canal originates from the deep scleral plexus in the embryonic stage, however it is not yet known whether the endothelium of the canal has the nature of a blood vessel or a lymphatic vessel. In this study, we investigated differences among the endothelia of the Schlemm canal, lymphatic vessel and blood vessel in the lung regarding the platelet coagulation system.

 
Methods:
 

Autopsy eyes, trabeculectomy specimens and normal lung tissue obtained from surgery were used in this study. The tissue was processed for paraffin sections, which were stained immunohistochemically using antibodies against von-Willebrand factor (vWF), PE-CAM and thrombomodulin, which modulate the platelet coagulation system. Immunohistochemical staining was also performed for these specimens using antibodies as markers of lymphatic vessels (D2-40) and blood vessels (CD34, E-selectin).

 
Results:
 

SCECs: Endothelium of the Schlemm canalLVECs: Endothelium of blood vessels in the lungLLECs: Endothelium of lymphatic vessels in the lung  

 
Conclusions:
 

The endothelium of the canal suppresses the platelet coagulation system more than those of lymphatic vessels in the lung. This suggested that the aqueous humor can pass smoothly from the inner wall free from the platelet coagulation system.

 
Keywords: trabecular meshwork • pathology: human • immunohistochemistry 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×