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M. J. Rojas, M. T. Garcia-Gutierrez, I. Fernandez, J. C. Pastor, M. Brion, B. Sobrino, A. Carracedo, R. M. Sanabria; Genetic Contribution to Proliferative Vitreoretinopathy Development. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1711. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
Proliferative vitreoretinopathy (PVR) is the main cause of failure of retinal detachment (RD) surgery and an important pitfall in the development of new surgical strategies for several intraocular disorders. Its pathogenesis is related to inflammation and scarring processes and, as suggested by a preliminary study, polymorphisms in pro-inflammatory cytokine genes may play a role in the development of PVR. The purpose of this study was to analize the potential genetic contribution to PVR development.
DNA of blood-samples from 138 patients with PVR following primary rhegmatogenous RD and 312 RD non-PVR matched controls in a candidate gene association study have been evaluated. A total of 224 single nucleotide polymorphisms (SNPs) from 30 candidate genes involved in inflammation were analyzed. Simple associations were established using x-squared test and exact Fisher's test and haplotypic analysis was performed by a score statistic. Results were corrected by False Discovery Rate (FDR) test.
Genetic markers for PVR development have been identified in 4 genes involved in inflammation process: TNF, TNFR2, SMAD7, and PI3KCG. (Patent pending).
Despite replication of these findings is mandatory, these results suggest a genetic contribution in PVR development. These findings could be used to identify new therapeutic targets for this complication.
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