May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Pseudoexfoliation Syndrome in India: Association of G135D Polymorphism in LOXL1 Gene
Author Affiliations & Notes
  • V. Ramprasad
    Genetics/Molec Bio, Vision Research Foundation, Chennai, India
  • R. George
    Department of Glaucoma, Medical Research Foundation, Sankara Nethralaya, Chennai, India
  • N. Soumittra
    Genetics/Molec Bio, Vision Research Foundation, Chennai, India
  • F. Sharmila
    Genetics/Molec Bio, Vision Research Foundation, Chennai, India
  • L. Vijaya
    Department of Glaucoma, Medical Research Foundation, Sankara Nethralaya, Chennai, India
  • G. Kumaramanickavel
    Genetics/Molec Bio, Vision Research Foundation, Chennai, India
  • Footnotes
    Commercial Relationships  V. Ramprasad, None; R. George, None; N. Soumittra, None; F. Sharmila, None; L. Vijaya, None; G. Kumaramanickavel, None.
  • Footnotes
    Support  Chennai Willingdon Corporate Foundation, India
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1722. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      V. Ramprasad, R. George, N. Soumittra, F. Sharmila, L. Vijaya, G. Kumaramanickavel; Pseudoexfoliation Syndrome in India: Association of G135D Polymorphism in LOXL1 Gene. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1722. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : In the Nordic, Anglo-Celtic & Caucasian populations, pseudoexfoliation syndrome (XFS) and pseudoexfoliation glaucoma (XFG) has been significantly associated with the LOXL1 gene exon 1 polymorphisms - allele G of rs1048661 (R141L) and allele G of rs3825942 (G135D). In this study, we studied the association of rs1048661 and rs3825942 in a southern Indian population.

Methods: : Sixty two cases with XFS and 120 matched normal controls who had thorough glaucoma evaluation were included in the study. Exon 1 of LOXL1 gene with the SNPs were amplified and sequenced. For statistical significance Pearson’s Chi square test was performed. HAPLOVIEW program v4.0 was used to determine the Hardy-Weinberg equilibrium and haplotype association.

Results: : In our study population there was a significant association of allele G of rs3825942 with XFS (p = 0.0001, OR = 4.17, CI - 1.89, 9.18) and genotype GG (p=0.000305) with XFS. Among the three observed haplotypes, G,G haplotype was strongly associated with XFS (OR of 3.001, CI - 1.83, 4.91, p = 9.9 x 10-6)

Keywords: genetics • gene mapping • gene/expression 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×