May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Comparison of Saccharides of Basal Laminar Drusen and Soft Drusen in Type Ii Mesangiocapillary Glomerulonephritis With Drusen in Age-Related Macular Degeneration
Author Affiliations & Notes
  • Y. Dsouza
    Medical Retina, Moorfields Eye Hospital, London, United Kingdom
  • R. E. Bonshek
    Academic Unit, Manchester Royal Eye Hospital, Manchester, United Kingdom
  • C. Short
    Nephrology, Manchester Royal Infirmary Hospital, Manchester, United Kingdom
  • C. J. P. Jones
    Maternal and Fetal Health Research Centre, University of Manchester, Manchester, United Kingdom
  • Footnotes
    Commercial Relationships  Y. Dsouza, None; R.E. Bonshek, None; C. Short, None; C.J.P. Jones, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1746. doi:https://doi.org/
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      Y. Dsouza, R. E. Bonshek, C. Short, C. J. P. Jones; Comparison of Saccharides of Basal Laminar Drusen and Soft Drusen in Type Ii Mesangiocapillary Glomerulonephritis With Drusen in Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1746. doi: https://doi.org/.

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Abstract

Purpose: : Patients with mesangiocapillary or membrano-proliferative glomerulonephritis type II (type II MCGN or type II MPGN) may develop numerous small tightly packed drusen termed basal laminar drusen (BLD) or large, soft drusen more typical of the age-related macular degeneration (AMD). We studied the oligosaccharide composition of drusen in MCGN type II and AMD using lectin histochemistry

Methods: : Formalin fixed and paraffin wax embedded tissue from both eyes of a 38 year old female who died from end-stage renal failure due to type II MCGN was compared with tissue from 6 eyes with AMD. The patient with type II MCGN had previously undergone fluorescein angiography which showed both BLD and soft drusen. Oligosaccharides were compared using a panel of twenty biotinylated lectins and an avidin-peroxidase DAB-cobalt revealing system, with and without neuraminidase pre-treatment.

Results: : The lectin-binding patterns of BLD and soft drusen in MCGN-II and AMD were similar.

Conclusions: : Drusen in AMD and MCGN-II may be a common end-result of a variety of systemic and ocular processes which is consistent with the literature that both may be a result of uncontrolled activation of the complement system.

Keywords: age-related macular degeneration • glycoconjugates/glycoproteins • drusen 
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