May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Characteristics of Early Age-Related Maculopathy of Chinese Population: the Beijing Eye Study
Author Affiliations & Notes
  • Y. Li
    Retina, Beijing Institute of Ophthalmology, Beijing, China
  • L. Xu
    Retina, Beijing Institute of Ophthalmology, Beijing, China
  • J. B. Jonas
    Ophthalmology, Mannheim of the Ruprecht-Karls-University of Heidelberg, Mannheim, Germany
  • Y. Gao
    Retina, Beijing Institute of Ophthalmology, Beijing, China
  • J. Li
    Retina, Beijing Institute of Ophthalmology, Beijing, China
  • H. Yang
    Retina, Beijing Institute of Ophthalmology, Beijing, China
  • Footnotes
    Commercial Relationships  Y. Li, None; L. Xu, None; J.B. Jonas, None; Y. Gao, None; J. Li, None; H. Yang, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1767. doi:
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    • Get Citation

      Y. Li, L. Xu, J. B. Jonas, Y. Gao, J. Li, H. Yang; Characteristics of Early Age-Related Maculopathy of Chinese Population: the Beijing Eye Study. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1767.

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Abstract

Purpose: : To evaluate the characteristics of early age-related maculopathy (ARM) in adult Chinese living in rural or urban regions of mainland China.

Methods: : The Beijing Eye Study is a population based prevalence study, which included 4439 out of 5324 subjects from a rural area and an urban region of greater Beijing, aged 40 years or older. The participants underwent a detailed ophthalmic examination including fundus photography. All fundus photographs were graded by the Wisconsin Age-Related Maculopathy Grading System.

Results: : Fundus photographs were available for 4376 (98.6%) subjects. Drusen was present in 15.3% of the subjects, while soft drusen in 6.47%. A marked age-related increase in soft drusen was observed (p=0.001), as the prevalence of soft drusen was 2.63% among people aged between 40-49 years, 5.72% among people aged between 50-59years, 9.30% among people aged between 60-69years, and 12.22% among people aged 70 years and older. Hypopigmentation was present in 13.28% of the subjects, of which prevalence was 11.57% among people aged between 40-49 years, 14.94% among people aged between 50-59years, 14.46% among people aged between 60-69years, and 11.39% among people aged 70 years and older. Hyperpigmentation was present in 4.6% of the subjects, of which prevalence was 3.6% among people aged between 40-49 years, 5.7% among people aged between 50-59years, 5.1% among people aged between 60-69years, and 3.4% among people aged 70 years and older. No marked age-related increase in soft drusen could be observed either in hypopigmentation or hyperpigmentation, also in early ARM when defined as absence of late AMD in addition to the presence of any drusen (except hard indistinct) or hypopigmentation/hyperpigmentation in the macular area. However, a marked age-related increase could be observed in early ARM when defined as absence of late AMD in addition to the presence of of soft indistinct drusen or any drusen (except hard indistinct) combined with pigment abnomality in the macular area.

Conclusions: : These data provide detailed prevalence and characteristics of most components of early ARM in a Chinese adult population.

Keywords: age-related macular degeneration • clinical (human) or epidemiologic studies: prevalence/incidence 
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