May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Protective Effects of Alleles in Inflammatory and Retinal Disease Genes in Age-Related Macular Degeneration: The Los Angeles Latino Eye Study
Author Affiliations & Notes
  • H. E. Volk
    University of Southern California, Los Angeles, California
    Preventive Medicine,
  • D. Van den Berg
    University of Southern California, Los Angeles, California
    Urology,
  • D. Conti
    University of Southern California, Los Angeles, California
    Preventive Medicine,
  • C. Shtir
    University of Southern California, Los Angeles, California
    Ophthalmology,
  • R. Varma
    University of Southern California, Los Angeles, California
    Ophthalmology,
  • LALES Group
    University of Southern California, Los Angeles, California
  • Footnotes
    Commercial Relationships  H.E. Volk, None; D. Van den Berg, None; D. Conti, None; C. Shtir, None; R. Varma, None.
  • Footnotes
    Support  NIH Grants EY-11753, EY-03040, ES-013678and unrestricted grant from Research to Prevent Blindness
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1768. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      H. E. Volk, D. Van den Berg, D. Conti, C. Shtir, R. Varma, LALES Group; Protective Effects of Alleles in Inflammatory and Retinal Disease Genes in Age-Related Macular Degeneration: The Los Angeles Latino Eye Study. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1768. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : Genes related to inflammation and retinal disease have been associated with age-related macular degeneration (AMD). These genes have also been shown to interact with smoking to increase risk. This study examines single nucleotide polymorphisms (SNPs) in apolipoprotein E (APOE), complement component 2 (C2), complement factor H (CFH), C-reactive protein (CRP), and EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) in relation to AMD risk.

Methods: : Prevalent AMD cases (n=218) and control subjects (n=218) were ascertained from the Los Angeles Latino Eye Study (LALES). AMD cases were identified by an age related eye disease study scale (AREDS) score ≥7. Controls had an AREDS score=0. Subjects were categorized as smokers if former or current smoking was reported during the study visit. Genotyping was carried out using the Illumina platform with tag SNPs selected to characterize ≥80% of the variation in each gene. Analyses were conducted assuming an additive model where the least frequent genotype conferred the greatest risk.

Results: : After adjusting for age, 15 SNPs in APOE, C2, and CFH were nominally (p<0.05) associated with AMD. Of these, 6 appear to be protective and 9 increase risk. Interaction with smoking status yielded nominally significant associations with 11 SNPs in EFEMP1 and CFH of which 10 were protective. After correction for multiple comparisons no main effects or interactions remained significant.

Conclusions: : Four of the genes examined reveal potential significant associations with AMD. Notably, many of these main effects and interactions appear to protect against the disease.

Keywords: age-related macular degeneration • genetics 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×