May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Electrically Evoked Cortical Potentials (EECP) in Rabbits Using Implantable Retinal Stimulation System
Author Affiliations & Notes
  • J. Zhou
    School of Electrical Engineering and Computer Science, Seoul National University, Seoul, Republic of Korea
    Nano Bioelectronics & Systems Research Center, Nano Artificial Vision Research Center, Seoul, Republic of Korea
  • S.-J. Woo
    Nano Bioelectronics & Systems Research Center, Nano Artificial Vision Research Center, Seoul, Republic of Korea
    Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Republic of Korea
  • K.-S. Min
    School of Electrical Engineering and Computer Science, Seoul National University, Seoul, Republic of Korea
    Nano Bioelectronics & Systems Research Center, Nano Artificial Vision Research Center, Seoul, Republic of Korea
  • H. Chung
    Nano Bioelectronics & Systems Research Center, Nano Artificial Vision Research Center, Seoul, Republic of Korea
    Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Republic of Korea
  • S.-J. Kim
    School of Electrical Engineering and Computer Science, Seoul National University, Seoul, Republic of Korea
    Nano Bioelectronics & Systems Research Center, Nano Artificial Vision Research Center, Seoul, Republic of Korea
  • Footnotes
    Commercial Relationships  J. Zhou, None; S. Woo, None; K. Min, None; H. Chung, None; S. Kim, None.
  • Footnotes
    Support  NBS-ERC Supported by KOSEF (Grant R11-2000-075-01001-0) & Korea Health 21 R&D Project MOHW A050251
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1774. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      J. Zhou, S.-J. Woo, K.-S. Min, H. Chung, S.-J. Kim; Electrically Evoked Cortical Potentials (EECP) in Rabbits Using Implantable Retinal Stimulation System. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1774. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : To remove external components from animals during long-term electrical stimulation experiments, implantable animal electrical retinal stimulator system was proposed. To evaluate the feasibility of the stimulator, electrically evoked cortical potentials were measured and analyzed in rabbits.

Methods: : The implantable retinal prosthesis system for a chronic animal experiment consisted of an internal unit for retinal stimulation and an external unit for stimulation control and battery recharge. Rechargeable internal battery and parameter memory component were introduced to the implanted retinal stimulator. Paired RF coils link these two units for data and power transmission. Polyimide-based seven-channel, strip-shaped gold electrode array was used as stimulating electrode. 4 mm x 4 mm sized stimulation part contains seven- segment configuration electrodes and another round electrode 1500 um in diameter was used as the reference one. The stimulation electrode array was implanted in the suprachoroidal space and the reference electrode was placed on the scleral surface of the opposite direction from the stimulation electrode. Evoked cortical potentials were recorded under visual or electrical stimulation of the retina, with titanium screw implanted in the skull over the visual cortex, and repetitive, cathodic-first biphasic stimuli were used as electrical stimulation.

Results: : The EECP were well recorded upon electrical stimulation with the implanted electrode array. EECP resembled visual evoked potential and showed dosimetric increment in the amplitude according to the increment of the stimulating current. The EECP disappeared after the optic nerves were severed, which showed the waveform recorded with the implanted titanium screw was not a noise generated by the electrical stimulation itself.

Conclusions: : The feasibility of implantable electrical retinal stimulator has been demonstrated. This stimulation system without attached external components during stimulation cycle might be used for the long-term animal experiments.

Keywords: retina • electrophysiology: non-clinical • retina 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×