May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Comparison of Activated Cortical Area Between Light and Electrical Stimulation in Rabbit Retina by Positron Emission Tomography
Author Affiliations & Notes
  • S. Woo
    Seoul National University School of Medicine, Seoul, Republic of Korea
    Ophthalmology,
    Nano Artificial Vision Research Center, Nano Bioelectronics & System Research Center, Seoul, Republic of Korea
  • J. Zhou
    Nano Artificial Vision Research Center, Nano Bioelectronics & System Research Center, Seoul, Republic of Korea
    School of Electrical Engineering and Computer Science, Seoul National University, Seoul, Republic of Korea
  • S. Kim
    Seoul National University School of Medicine, Seoul, Republic of Korea
    Nuclear Medicine,
  • T. Kim
    Seoul National University School of Medicine, Seoul, Republic of Korea
    Ophthalmology,
    Nano Artificial Vision Research Center, Nano Bioelectronics & System Research Center, Seoul, Republic of Korea
  • J.-M. Seo
    Nano Artificial Vision Research Center, Nano Bioelectronics & System Research Center, Seoul, Republic of Korea
    School of Electrical Engineering and Computer Science, Seoul National University, Seoul, Republic of Korea
  • J. Lee
    Seoul National University School of Medicine, Seoul, Republic of Korea
    Nuclear Medicine,
  • D. Lee
    Seoul National University School of Medicine, Seoul, Republic of Korea
    Nuclear Medicine,
  • H. Yu
    Seoul National University School of Medicine, Seoul, Republic of Korea
    Ophthalmology,
    Nano Artificial Vision Research Center, Nano Bioelectronics & System Research Center, Seoul, Republic of Korea
  • S. Kim
    Nano Artificial Vision Research Center, Nano Bioelectronics & System Research Center, Seoul, Republic of Korea
    School of Electrical Engineering and Computer Science, Seoul National University, Seoul, Republic of Korea
  • H. Chung
    Seoul National University School of Medicine, Seoul, Republic of Korea
    Ophthalmology,
    Nano Artificial Vision Research Center, Nano Bioelectronics & System Research Center, Seoul, Republic of Korea
  • Footnotes
    Commercial Relationships  S. Woo, None; J. Zhou, None; S. Kim, None; T. Kim, None; J. Seo, None; J. Lee, None; D. Lee, None; H. Yu, None; S. Kim, None; H. Chung, None.
  • Footnotes
    Support  Korea Health 21 R&D Project MOHW A050251, NBS-ERC supported by KOSEF
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1776. doi:https://doi.org/
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      S. Woo, J. Zhou, S. Kim, T. Kim, J.-M. Seo, J. Lee, D. Lee, H. Yu, S. Kim, H. Chung; Comparison of Activated Cortical Area Between Light and Electrical Stimulation in Rabbit Retina by Positron Emission Tomography. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1776. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Electrical stimulation of the retina can elicit cortical potentials in animals and phosphenes in humans. (Dowling 2005, Weiland 2005) By using positron emission tomography (PET), the cortical areas of a rabbit activated by light and electrical stimuli were evaluated and the nature of the electrically evoked visual perception was analyzed by comparing the two activated cortical images.

Methods: : New Zealand white rabbit weighing 3.0kg was used in the study. Static PET data with 10 min duration was acquired 30 min after injection of 18F-fluorodeoxyglucose (18F-FDG, 37 MBq) through the catheter placed in the ear vein. The resting PET study was done without stimuli. For the light stimulation PET studies, repetitive flash light stimulation of whole visual field (0.3 Hz, 6 min total) was applied on one eye 1 min prior to FDG injection. For the electrical stimulation PET studies, repetitive electrical retinal stimulation (500µA, 1 Hz, 6 min total) was applied on the same eye with light stimulation using a suprachoroidal polyimide electrode array placed under the visual streak. Each study was performed on different day. All images were realigned to the resting state image. The quantitative change of cerebral glucose metabolism was determined from the difference between the resting and stimulation state. To remove the effects of global differences, each voxel value of the images was normalized by the mean value of the whole brain.

Results: : After visual and electrical stimulation of the rabbit retina, the cerebral areas of increased metabolism could be localized on PET study. The activated cortical area after electrical retinal stimulation overlapped and confined within the visually activated cortical area.

Conclusions: : The PET study showed increased metabolism of the same cortical area on light and electrical stimulation of the rabbit retina, which indicated electrical retinal stimulation could induce visual perception similar to the light stimulation in the rabbit.

Keywords: retina • visual cortex 
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